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- Title
THE EFFECTS OF NEW 1,3-THIAZOLIDINE-4-ONES WITH PYRRAZOLONE SCAFOLD ON MOTOR FUNCTION IN MICE.
- Authors
APOTROSOAEI, MARIA; VASINCU, IOANA MIRELA; CONSTANTIN, SANDRA MĂDĂLINA; IACOB, ANDREEA-TEODORA; TAUȘER, GEORGIANA-ROXANA; LUPAȘCU, DAN; LUPUȘORU, CĂTĂLINA-ELENA; PROFIRE, LENUȚA
- Abstract
The aim of this study was to investigate the effects of new 1,3-thizolidine-4-ones with pyrazolone scaffold (7a-m) on motor function in mice, using RotaRod performance and spontaneous locomotor activity tests. The toxicity screening of these compounds was also performed. The results of RotaRod performance test showed that the compounds don't have appreciable negative influence on neuromuscular activity, the recorded values being comparable with those of phenazone and control, so it could be appreciated that these compounds don't have neurotoxic effects. In the case of spontaneous locomotor activity test, the most intense negative effect was observed for 7j (3-OH,4-OCH3), for which the horizontal and vertical movements were lower than phenazone and control at all three-time intervals (1h, 2h, 4h). For other derivatives no appreciable negative effect on spontaneous locomotor activity was observed. Referring to the toxicity degree, all tested compounds showed lower toxicity in reference with phenazone, which supports the favourable influence of 1,3-thiazolidine-4-one moiety on pyrazolone scaffold.
- Subjects
MICE; MOTORS; AGRICULTURAL industries
- Publication
Farmacia, 2019, Vol 67, Issue 2, p305
- ISSN
0014-8237
- Publication type
Article
- DOI
10.31925/farmacia.2019.2.15