We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
BIOAVAILABILITY OF VALPROATE SUPPOSITORIES FORMULATED FOR PAEDIATRIC USE.
- Authors
TODORAN, NICOLETA; CIURBA, ADRIANA; VANCEA, SZENDE; VARI, CAMIL-EUGEN; DOGARU, MARIA-TITICA; TĂUREAN, ALEXANDRINA; MUNTEAN, DANIELA-LUCIA; VLAD, ROBERT-ALEXANDRU; GLIGOR, FELICIA
- Abstract
Considering that the rectal route might eliminate the time-dependent changes of valproic acid kinetics and starting from the need to develop suppositories for paediatric use, in our previous studies three types of valproate suppositories were selected for further in vivo investigation. In this paper, the experimental pharmacokinetic study conducted on rabbits is presented, in order to evaluate the relevant in vivo pharmacokinetic parameters. The parameters obtained after a single rectal dose over a period of 8 h, were analysed in each case by the non-compartmental pharmacokinetic model. The similarity of the three release profiles previously found in vitro has not fully confirmed the in vivo parameters, which shows that the in vivo pharmacokinetic test still remains necessary in case of studies on the development of suppositories formulation.
- Subjects
BIOAVAILABILITY; VALPROIC acid; SUPPOSITORIES; PHARMACOKINETICS; PEDIATRIC therapy
- Publication
Farmacia, 2017, Vol 65, Issue 5, p741
- ISSN
0014-8237
- Publication type
Article