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- Title
Anti-müllerian Hormone Associated with Antral Follicular Count in Cases of Polycystic Ovary Syndrome.
- Authors
Talib, Raghad Numan; Razzak, Maysaloon Adnan Abdul
- Abstract
Background: Anti-Müllerian hormone (AMH) synthesized in the "granulosa cells" of the ovarian graffian follicles and can suppress the growth of primordial follicles. Objective: To assess the AMH association with antral follicular count on the 2nd menstrual day to evaluate its diagnostic potency in the definition of polycystic ovary syndrome (PCOS). Patients and methods: |A case control study, involving two groups of total hundred infertile women. The first group included fifty PCOS cases, while the controls included 50 non-PCOS infertile cases. Detailed history was obtained from candidates, and on the 2-3 cycle day underwent the following hematological tests: testosterone, follicular stimulating hormone, AMH, luteinizing hormone, and estradiol. As well, transvaginal ultrasonography was performed to assess hormonal/follicular association evaluated by the count of early antral follicles. Results: The AMH levels in the PCOS were significantly higher compared to the controls (13.8±5.9 vs. 6.0±2.6ng/ml), correspondingly. A significant increase in the follicles' count among PCOS women compared to control (17.6±6.8 vs. 8.0±3.8), respectively. AMH correlated significantly high with follicular count in the PCOS group. The levels of AMH and testosterone were significantly correlated in the PCOS group. Conclusion: During the initial follicular phase, AMH in PCOS is strongly correlated with antral follicle status. Such a link is stronger when compared with other hormones affecting follicular function. This could highlight the importance of AMH concentration as superior predictor of the early follicular counts than traditional hormonal assays. Hence, AMH levels offer a good diagnostic potency in the definition of PCOS.
- Subjects
ANTI-Mullerian hormone; POLYCYSTIC ovary syndrome; OVARIAN follicle; TRANSVAGINAL ultrasonography; GRANULOSA cells; CANCER cell growth; MENSTRUATION disorders
- Publication
Kerbala Jorunal of Medicine, 2022, Vol 15, Issue 2, p2606
- ISSN
1990-5483
- Publication type
Article