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- Title
Longevity and Age-Related Pathology of Mice Deficient in Pregnancy-Associated Plasma Protein-A.
- Authors
Conover, Cheryl A.; Bale, Laurie K.; Mader, Jessica R.; Mason, Megan A.; Keenan, Kevin P.; Marler, Ronald J.
- Abstract
The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal circulating IGF-I levels. In this study, PAPP-A KO mice had significantly increased mean (27%), median (27%), and maximum (35%) life span compared with wild-type (WT) littermates. End-of-life pathology indicated that the incidence of neoplastic disease was not significantly different in the two groups of mice; however, it occurred in older aged PAPP-A KO compared with WT mice. Furthermore, PAPP-A KO mice were less likely to show degenerative changes of age. Scheduled pathologies at 78, 104, and 130 weeks of age indicated that WT mice, in general, had more degenerative changes and tumors earlier than PAPP-A KO mice. This was particularly true for abnormalities in heart, testes, brain, kidney, spleen, and thymus. In summary, the major contributors to the extended life span of PAPP-A KO mice are delayed occurrence of fatal neoplasias and decreased incidence of age-related degenerative changes.
- Subjects
LIFE spans; SOMATOMEDIN; DEGENERATION (Pathology); BLOOD proteins
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2010, Vol 65A, Issue 6, p590
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glq032