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- Title
Amygdala protein kinase C epsilon controls alcohol consumption.
- Authors
Lesscher, H. M. B.; Wallace, M. J.; Zeng, L.; Wang, V.; Deitchman, J. K.; McMahon, T.; Messing, R. O.; Newton, P. M.
- Abstract
Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCℇ) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCℇ signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCℇ in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice that are heterozygous for the PKCℇ allele consume less ethanol compared with wild-type mice in this paradigm. These mice have a >50% reduction in the abundance of PKCℇ in the amygdala compared with wild-type mice. We conclude that amygdala PKCℇ is important for ethanol consumption in mice.
- Subjects
ALCOHOLISM; AMYGDALOID body; LABORATORY mice; RNA; PROTEIN kinases; ALCOHOL; SUBSTANCE abuse
- Publication
Genes, Brain & Behavior, 2009, Vol 8, Issue 5, p493
- ISSN
1601-1848
- Publication type
Article
- DOI
10.1111/j.1601-183X.2009.00485.x