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- Title
CORRELATION OF ISCHEMIA‐MODIFIED ALBUMIN AND MICROALBUMINURIA.
- Authors
İPTEÇ, Betül ÖZBEK; AYDIN, Almila ŞENAT; NAR, Dursun; KOZACI, Leyla Didem; NEŞELİOĞLU, Salim; EREL, Özcan
- Abstract
Introduction: Microalbuminuria is the daily excretion of 30‐300 mg of albumin. The presence of albumin in the urine is generally considered abnormal even in trace amounts, although some healthy individuals exhibit albuminuria following intense exercise. Ischemia‐modified albumin (IMA) is a form of albumin in which the first two amino‐acids (Asp‐Ala) at N‐terminus has cleaved due to ischemia. Goal of this study is to find a relationship between serum IMA and 24‐hour urine microalbumin. Material and Methods: 45 patients were enrolled in the study who applied to Ankara Ataturk Training and Research Hospital from February 2017 to April 2017. Correlation of IMA and 24‐hour urine microalbumin values were investigated by using SPSS 22.0. Results: 24‐hour urine microalbumin levels were significantly correlated with IMA (r= 0.462, p=0.001). Also significant high negative correlation was found between 24‐hour urine microalbumin and serum albumin (r=‐0.716, p<0.001). Discussion: As the level of albumin excretion in urine increases, the serum albumin levels decrease. This relationship reveals the significant high negative correlation between microalbuminuria and albumin. According to some studies, elevation of oxidative stress in body results increase in IMA concentration. Microalbuminuria indicates an injury in kidneys which are responsible from excreting waste and oxidant products by urine. Deterioration of this mechanism cause increased oxidative stress in body and this state may lead to elevated IMA levels. Moreover negative correlation of IMA and microalbuminuria can be explained by the inverse correlation between IMA and albumin.
- Subjects
ISCHEMIA; URINE; ALBUMINURIA
- Publication
Ankara Medical Journal, 2017, p31
- ISSN
2148-4570
- Publication type
Abstract