We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intratumoral heterogeneity in breast cancer – a real challenge for diagnosis and treatment.
- Authors
Pirciu, Marius; Avram, Elena; Augustin, Iolanda Georgiana; Zob, Daniela; Lăzescu, Andreea
- Abstract
We present the case of a patient with breast neoplasm which presented a particular evolution with pronounced molecular intratumoral heterogeneity proven at multiple biopsies. If in the first instance, at the primary tumor it was discovered a negative molecular HER2 luminal B pattern, in the end stage, after treatment with neoadjuvant chemotherapy, the residual tumor from the mastectomy tissue presented a luminal B profile with HER2 amplification. Under targeted anti-HER2 treatment, there was cutaneous and pleural progression, lesions that were subjected to biopsy and which revealed the presence of secondary masses with triple negative molecular pattern.
- Subjects
BREAST cancer; TRIPLE-negative breast cancer; HETEROGENEITY; BREAST tumors; PLEURAL effusions; NEOADJUVANT chemotherapy
- Publication
Oncolog-Hematolog, 2022, Issue 58, p42
- ISSN
2066-8716
- Publication type
Article