We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacognostic Study, Diuretic Activity and Acute Oral Toxicity of the Leaves of Xiphidium caeruleum Aubl. Collected in Two Different Phenological Stages.
- Authors
Gutiérrez Gaitén, Yamilet I.; Felipe González, Alejandro; Scull Lizama, Ramón; Núñez Cairo, Carlos R.; Álvarez Hernández, Greisa L.; Díaz Masó, Venancio; Noa Rodríguez, Ana C.; Herrera Isidrón, José A.; Pieters, Luc; Foubert, Kenn; Herrera Isidrón, Lisset
- Abstract
Xiphidium caeruleum Aubl. is traditionally used in Cuba as an analgesic, anti-inflammatory, antilithiatic and diuretic remedy. Here we studied the pharmacognostic parameters of the leaves of X. caeruleum, the preliminary phytochemical composition, diuretic activity and acute oral toxicity of the aqueous extracts from the leaves of plants collected in the vegetative (VE) and flowering (FE) stages. The morphological characteristics and physicochemical parameters of leaves and extracts were determined. The phytochemical composition was assessed by phytochemical screening, TLC, UV, IR and HPLC/DAD profiles. The diuretic activity was evaluated in Wistar rats and compared to furosemide, hydrochlorothiazide and spironolactone. Epidermal cells, stomata and crystals were observed on the leaf surface. Phenolic compounds were identified as the main metabolites, including phenolic acids (gallic, caffeic, ferulic and cinnamic acids) and flavonoids (catechin, kaempferol-3-O-glucoside and quercetin). VE and FE showed diuretic activity. The activity of VE was similar to furosemide, and the activity of FE resembled spironolactone. No acute oral toxicity was observed. The presence of flavonoids and phenols in VE and FE may explain at least in part the traditional use and provide some insight into the reported ethnomedical use as a diuretic. Because of the differences in polyphenol profiles between VE and FE, further studies should be carried out to standardize the harvesting and extraction conditions in order to use X. caeruleum leaf extract as herbal medicine.
- Subjects
CUBA; DIURETICS; FERULIC acid; CINNAMIC acid; PLANT polyphenols; PHENOLS; PHENOLIC acids; LABORATORY rats
- Publication
Plants (2223-7747), 2023, Vol 12, Issue 6, p1268
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants12061268