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- Title
A Phase II Study of S‐1 and Paclitaxel Combination Therapy as a First‐Line Treatment in Elderly Patients with Advanced Non‐Small Cell Lung Cancer.
- Authors
Yoshimura, Akihiro; Chihara, Yusuke; Date, Koji; Tamiya, Nobuyo; Takemura, Yoshizumi; Imabayashi, Tatsuya; Kaneko, Yoshiko; Yamada, Tadaaki; Ueda, Mikio; Arimoto, Taichiro; Uchino, Junji; Iwasaki, Yoshinobu; Takayama, Koichi
- Abstract
Lessons Learned: Coadministration of S‐1 and paclitaxel in elderly patients with advanced non‐small cell lung cancer showed favorable efficacy.Coadministration of S‐1 and paclitaxel in elderly patients with advanced non‐small lung cancer showed tolerable toxicity. Background: Although monotherapy with cytotoxic agents including docetaxel or vinorelbine are recommended for elderly patients with advanced non‐small cell lung cancer (NSCLC), the outcome is not satisfactory. We evaluated the efficacy and safety of S‐1 and paclitaxel (PTX) as a first‐line cotreatment in elderly patients with advanced NSCLC. Methods: Oral S‐1 was administered on days 1–14 every 3 weeks at 80, 100, and 120 mg per day for patients with body surface area < 1.25 m2, 1.25–1.5 m2, and > 1.5 m2, respectively. PTX was administered at 80 mg/m2 on days 1 and 8. The primary endpoint was response rate, and secondary endpoints were progression‐free survival (PFS), overall survival (OS), and safety. Results: Seventeen patients were enrolled with response and disease control rates of 47.1% and 88.2%, respectively. Median PFS and OS were 5.6 and 35.0 months, respectively. Hematological grade 3 or 4 toxicities included leukopenia (55.8%), neutropenia (52.9%), febrile neutropenia (11.8%), and anemia (11.8%). Nonhematological grade 3 toxicities included stomatitis (23.5%), diarrhea (5.9%), and interstitial lung disease (5.9%), and grade 5 toxicities included interstitial lung disease (5.9%). Conclusion: This S‐1 and PTX cotherapy dose and schedule showed satisfactory efficacy with mild toxicities in elderly patients with advanced NSCLC.
- Subjects
ANTINEOPLASTIC agents; LUNG cancer prevention; LUNG cancer prognosis; ELDER care; ANEMIA; BLOOD diseases; CLINICAL trials; DIARRHEA; DRUG toxicity; FEBRILE neutropenia; FLUOROURACIL; HETEROCYCLIC compounds; INTERSTITIAL lung diseases; LEUCOPENIA; LUNG cancer; NEUTROPENIA; ORAL drug administration; PACLITAXEL; STOMATITIS; SURVIVAL; TUMOR classification; TREATMENT effectiveness; BODY surface area; DISEASE progression; OLD age
- Publication
Oncologist, 2019, Vol 24, Issue 4, p459
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2018-0858