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- Title
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment.
- Authors
Rauskolb, Stefanie; Andreska, Thomas; Fries, Sophie; von Collenberg, Cora Ruedt; Blum, Robert; Monoranu, Camelia-Maria; Villmann, Carmen; Sendtner, Michael
- Abstract
Risk factors such as dysregulation of Insulin-like growth factor (IGF) signaling have been linked to Alzheimer's disease. Here we show that Insulin-like Growth Factor Binding Protein 5 (Igfbp5), an inhibitory binding protein for insulin-like growth factor 1 (Igf-1) accumulates in hippocampal pyramidal neurons and in amyloid plaques in brains of Alzheimer patients. We investigated the pathogenic relevance of this finding with transgenic mice overexpressing Igfbp5 in pyramidal neurons of the brain. Neuronal overexpression of Igfbp5 prevents the training-induced increase of hippocampal and cortical Bdnf expression and reduces the effects of exercise on memory retention, but not on learning acquisition. Hence, elevated IGFBP5 expression could be responsible for some of the early cognitive deficits that occur during the course of Alzheimer's disease.
- Subjects
SOMATOMEDIN; INSULIN-like growth factor-binding proteins; SOMATOMEDIN C; PYRAMIDAL neurons; ALZHEIMER'S disease
- Publication
Acta Neuropathologica Communications, 2022, Vol 10, Issue 1, p1
- ISSN
2051-5960
- Publication type
Article
- DOI
10.1186/s40478-022-01352-5