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- Title
Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species.
- Authors
Wu, Juanjuan; Hansen, Jason M.; Hao, Lijuan; Taylor, Robert N.; Sidell, Neil
- Abstract
Vascular endothelial growth factor (VEGF) is an angiogenic factor that plays a primary role in blood vessel development in uterine endometrial tissue during embryo implantation and early growth. Previously, we determined that retinoic acid (RA) can act as a co-factor to rapidly induce VEGF secretion from human endometrial stromal cells. We show here that stimulation of VEGF by RA is directly mediated by increased production of reactive oxygen species (ROS) in these cells. These findings predict a ROS-mediated mechanism for RA regulation of localized VEGF secretion in the human endometrium that may be necessary for the successful establishment of pregnancy. The results obtained may provide new targets for therapeutic intervention.
- Publication
Journal of Physiology, 2011, Vol 589, Issue 4, p863
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2010.200808