We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Falla en la producción de anticuerpos con la vacuna del virus de la hepatitis B en pacientes dializados: incidencia y factores asociados.
- Authors
Aguirre Caicedo, Marcelo; Molina, Francisco; Giraldo, Nelson; Uribe Betancur, Mauricio
- Abstract
Objective: to get to know the incidence of non-seroconversion after vaccination for hepatitis B in dialysis patients, and to establish the associated factors with the lack of antibody production. Methods: multicenter retrospective cohort study in Medellin. Patients with chronic renal failure who started hemodialysis or peritoneal dialysis between January 2006 and June 2008 were included. Vaccination schedule: 4 doses of 40 mcg Hepavax- Gene ®, with measurement of antibodies 4 weeks later. A lack of response was considered if: titles <10 U. We analyzed gender, age, race, diabetes, blood transfusions, erythropoietin, creatinine, ferritin, hemoglobin, albumin, and type of dialysis. Binary logistic regression was done to identify associated factors with the vaccination response and multiple linear regression "stepwise" to predict the levels of antibodies Results: 237 patients were included. That reached protective antibody titers 153 patients (63.9%). The response prediction formula is: Ln Y = (1.88) + (0.97 X Albumin) - (0.00024 X Age) - (0.097 X Creatinine) - (0.47 X Women) - (0.49 X Hemodialysis), Y= antibody title. The albumin greater than 3 g/dl was associated with titers greater than 10 U. OR = 4.92, (95% CI 2.09 - 12.37). Conclusions: the incidence of the seroconversion after vaccination against the virus of hepatitis B in patients in dialysis is 63%. The elderly (> 65 years old) and hypoalbuminemia (<3 g/dl) were associated to a smaller response to the vaccination.
- Subjects
IMMUNOGLOBULINS; HEPATITIS B vaccines; SEROCONVERSION; HEMODIALYSIS patients; BLOOD transfusion; ERYTHROPOIETIN
- Publication
Medicina UPB, 2011, Vol 30, Issue 2, p141
- ISSN
0120-4874
- Publication type
Article