We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oxalate-degrading microorganisms or oxalate-degrading enzymes: which is the future therapy for enzymatic dissolution of calcium-oxalate uroliths in recurrent stone disease?
- Authors
Peck, Ammon; Canales, Benjamin; Nguyen, Cuong
- Abstract
Renal urolithiasis is a pathological condition common to a multitude of genetic, physiological and nutritional disorders, ranging from general hyperoxaluria to obesity. The concept of quickly dissolving renal uroliths via chemolysis, especially calcium-oxalate kidney stones, has long been a clinical goal, but yet to be achieved. Over the past 25 years, there has been a serious effort to examine the prospects of using plant and microbial oxalate-degrading enzymes known to catabolize oxalic acid and oxalate salts. While evidence is emerging that bacterial probiotics can reduce recurrent calcium-oxalate kidney stone disease by lowering systemic hyperoxaluria, the possible use of free oxalate-degrading enzyme therapy remains a challenge with several hurdles to overcome before reaching clinical practice.
- Subjects
CALCIUM oxalate; RENAL colic; KIDNEY stones; URINARY calculi; THERAPEUTICS; DIAGNOSIS; MEDICAL care; MICROBIOLOGY
- Publication
Urolithiasis, 2016, Vol 44, Issue 1, p45
- ISSN
2194-7228
- Publication type
Article
- DOI
10.1007/s00240-015-0845-6