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- Title
The potential role of ERβ isoforms in the clinical management of breast cancer.
- Authors
Green, C. A.; Peter, M. B.; Speirs, V.; Shaaban, A. M.
- Abstract
The discovery of a second oestrogen receptor, ERβ, was a subject of much interest, as this suggested a means to improve the prognostic stratification of invasive breast cancer, better predict response to endocrine therapy, develop new chemotherapeutic/chemopreventative drugs and perhaps prevent inappropriate treatment. However, this has not proved to be straightforward with the discovery of five ERβ isoforms and numerous exon deletion variants. This review sets out to identify the present state of knowledge regarding the clinicopathological role of ERβ isoforms and discusses possible reasons for conflicting results arising from recent research findings.
- Subjects
DISEASE management; BREAST cancer; HORMONE therapy; STEROID hormones; CANCER prognosis; CANCER treatment
- Publication
Histopathology, 2008, Vol 53, Issue 4, p374
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2008.02968.x