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- Title
Hematological Manifestations of Dengue, Malaria and Enteric Fever in Children Presenting To a Tertiary Care Hospital, Pakistan.
- Authors
Nasir, Sharmeen; Rafique, Muhammad; Jamal, Ammarah; Jamalvi, Waseem; Yahya, Yousuf
- Abstract
Objective: Dengue fever, Malaria and Enteric fever are common pediatric acute febrile illnesses, presenting with overlapping clinical manifestations. The hematological parameters of these disease may give a clue to the specific diagnosis before definitive investigations are available. W e designed this study to determine the hematological predictors of dengue fever, malaria and enteric fever in pediatric inpatient population. Methods: We collected data for this observational study from May to October 2022 from Pediatrics Department, Dr. RKMP Civil Hospital Karachi. We reviewed the medical records of patients 1 month to 12 years of age admitted with definitive diagnosis of dengue, malaria and/or enteric fever. We recorded the demographic and clinical variables and hematologic parameters of Complete Blood Count and calculated the P value and sensitivity / specificity of each parameter in SPSS 22.0, for differentiating the three diseases. Results: A total of 205 patients were included in the study, out of which 82 (40%) had malaria, 71 (34.6%) had dengue and 52 (25.4%) had enteric fever. Male gender was predominant in 73.6%. Patients with dengue fever mostly had normal hemoglobin (>11gm/dl) with a higher hematocrit, lymphopenia (<40%) and thrombocytopenia (50,000-100000/ul), while in enteric fever moderate anemia (7-9gm/dl) with normal TLC and platelet count was mostly found and for malaria severe anemia (<7gm/dl) and thrombocytopenia (<50,000/ul) with a normal TLC count were predictive of disease (P value<0.05). Conclusion: Lymphopenia and Thrombocytopenia are predictors of dengue fever, moderate anemia with preserved platelet count suggests enteric fever while severe anemia and thrombocytopenia should predict malaria in the appropriate clinical setting.
- Subjects
KARACHI (Pakistan); PAKISTAN; TYPHOID fever; DENGUE hemorrhagic fever; BLOOD diseases; MALARIA; SYMPTOMS; BLOOD cell count
- Publication
Annals of Abbasi Shaheed Hospital & Karachi Medical & Dental College, 2024, Vol 29, Issue 2, p172
- ISSN
1563-3241
- Publication type
Article
- DOI
10.58397/ashkmdc.v29i2.710