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- Title
MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight.
- Authors
Ruiz-Manriquez, Luis M.; Carrasco-Morales, Oscar; Sanchez Z., E. Adrian; Osorio-Perez, Sofía Madeline; Estrada-Meza, Carolina; Pathak, Surajit; Banerjee, Antara; Bandyopadhyay, Anindya; Duttaroy, Asim K.; Paul, Sujay
- Abstract
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. The molecular pathogenesis of HCC varies due to the different etiologies and genotoxic insults. The development of HCC is characterized by complex interactions between several etiological factors that result in genetic and epigenetic changes in proto-onco and/or tumor suppressor genes. MicroRNAs (miRNAs) are short non-coding RNAs that also can act as oncomiRs or tumor suppressors regulating the expression of cancer-associated genes post-transcriptionally. Studies revealed that several microRNAs are directly or indirectly involved in cellular signaling, and dysregulation of those miRNAs in the body fluids or tissues potentially affects key signaling pathways resulting in carcinogenesis. Therefore, in this mini-review, we discussed recent progress in microRNA-mediated regulation of crucial signaling networks during HCC development, concentrating on the most relevant ones such as PI3K/Akt/mTOR, Hippo-YAP/TAZ, and Wnt/ß-catenin, which might open new avenues in HCC management.
- Subjects
HEPATOCELLULAR carcinoma; CELLULAR signal transduction; NON-coding RNA; CELL communication; LIVER cancer; TUMOR suppressor genes; REGULATION of body fluids; CATENINS
- Publication
Frontiers in Genetics, 2022, Vol 13, p1
- ISSN
1664-8021
- Publication type
Article
- DOI
10.3389/fgene.2022.910733