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- Title
Structural Development of Human Fetal and Preterm Brain Cortical Plate Based on Population-Averaged Templates.
- Authors
Qiaowen Yu; Austin Ouyang; Lina Chalak; Tina Jeon; Jonathan Chia; Mishra, Virendra; Sivarajan, Muraleedharan; Jackson, Greg; Rollins, Nancy; Shuwei Liu; Hao Huang
- Abstract
We hypothesized that the distinct maturational processes take place across different cortical areas from middle fetal stage to normal time of birth and these maturational processes are altered in late third trimester. Fractional anisotropies (FA) from diffusion tensor imaging (DTI) infer the microstructures of the early developing cortical plate. High-resolution DTI of 11 fetal brain specimens at postmenstrual age of 20weeks (or simplified as 20weeks), 19 in vivo brains at 35weeks, and 17 in vivo brains at normal time of birth at term (40weeks)were acquired. Population-averaged age-specific DTI templateswere established with large deformation diffeomorphic metric mapping for subject groups at 20, 35, and 40 weeks. To alleviate partial volume effects, skeletonized FAvalues were used for mapping averaged cortical FA to the cortical surface and measuring FA at 12 functionally distinctive cortical regions. Significant and heterogeneous FA decreases take place in distinct cortical areas from 20 to 35 weeks and from35 to 40weeks, suggesting differentiated cortical development patterns. Temporally nonuniform FA decrease patterns during 35-40 weeks compared with those during 20-35 weeks were observed in higher-order association cortex. Measured skeletonized FA suggested dissociated changes between cerebral cortex and white matter during 35-40 weeks.
- Publication
Cerebral Cortex, 2016, Vol 26, Issue 11, p4381
- ISSN
1047-3211
- Publication type
Article
- DOI
10.1093/cercor/bhv201