We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Viola odorata as an Add-On Therapy on Insomnia in Patients with Obsession or Depression: A Pilot Randomized Double-Blind Placebo-Controlled Trial.
- Authors
Shayesteh, Maryam; Vaez-Mahdavi, Mohammad-Reza; Shams, Jamal; Kamalinejad, Mohammad; Faghihzadeh, Soghrat; Gholami-Fesharaki, Mohammad; Gharebaghi, Reza; Heidary, Fatemeh
- Abstract
Objective: The present study was conducted to investigate the effect of Viola odorata extracted syrup on the quality and patterns of sleep in patients with depression or obsessive–compulsive disorder (OCD) as add-on therapy. Design: A pilot double-blind randomized placebo-controlled trial. Settings/Location: Psychiatric Clinic of Imam Hossein Hospital, Tehran, Iran. Subjects: Participants were 16–15 years of age with mild and moderate depression or OCD having insomnia. Interventions: This pilot study was conducted on patients with insomnia divided into two groups with depression (40 patients) or OCD (43 patients). Each group randomly assigned into two arms with the same conditions at baseline. The intervention arm daily received 5 mL V. odorata syrup every 12 h for 4 weeks, and the control arm received 5 mL placebo syrup every 12 h for 4 weeks. None of the participants was deprived of their routine treatment for depression or OCD. Outcome measures: The scores of insomnia symptoms were evaluated using total score of the Pittsburgh Sleep Quality Index (PSQI) and the scores of its components, the depression score using the final Beck depression inventory-II (BDI-II) score, and OCD score using the Yale–Brown Obsessive–Compulsive Scale (YBOCS). Results: The total PSQI score was found to be improved significantly in the intervention arms with depression or OCD (p < 0.001) compared with the corresponding control arms. Significant improvements were also observed in the final mean difference of BDI-II (p = 0.009) and YBOCS (p = 0.001) scores in the intervention arms. Conclusions:V. odorata syrup significantly improved insomnia symptoms and the scores of depression and OCD.
- Subjects
IRAN; THERAPEUTIC use of plant extracts; HYPOTHESIS; ANALYSIS of variance; MENTAL depression; INSOMNIA; INTERVIEWING; CLASSIFICATION of mental disorders; OBSESSIVE-compulsive disorder; HEALTH outcome assessment; PLACEBOS; PSYCHOLOGICAL tests; QUESTIONNAIRES; STATISTICAL sampling; SLEEP; T-test (Statistics); TIME; PLANT extracts; SAMPLE size (Statistics); PILOT projects; STATISTICAL significance; RANDOMIZED controlled trials; BLIND experiment; TREATMENT duration; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; KRUSKAL-Wallis Test
- Publication
Journal of Alternative & Complementary Medicine, 2020, Vol 26, Issue 5, p398
- ISSN
1075-5535
- Publication type
Article
- DOI
10.1089/acm.2019.0254