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- Title
Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial.
- Authors
Swanson, Barbara; Keithley, Joyce; Baum, Linda; Leurgans, Sue; Adeyemi, Oluwatoyin; Barnes, Lisa L.; Mata, Mariana; Rosdil, Anneliese
- Abstract
<bold> Objective: </bold> To explore the safety and efficacy of fish oil to modulate parameters of inflammation and immunosenescence in HIV-infected older adults. <bold> Design: </bold> This study uses a randomized, controlled, double-blind clinical trial. <bold> Setting: </bold> The study was conducted in an outpatient HIV/AIDS clinic in a large urban Midwestern city in the United States. <bold> Subjects: </bold> A total of 37 clinically stable HIV-infected adults between the ages of 40 and 70 years of age participated. <bold> Interventions: </bold> Fish oil 1.6 g/day was administered for 12 weeks or placebo. <bold> Outcome measures: </bold> Inflammatory cytokine production, surface markers of immunosenescence, and adverse events were measured. <bold> Results: </bold> After 12 weeks of supplementation, there were no significant differences between the treatment and control groups on any measures of inflammation or immunosenescence in both CD4+ and CD8+ T lymphocytes. More participants in the treatment group reported adverse gastrointestinal events compared with the control group. <bold> Conclusions: </bold> A 12-week supplementation regimen of 1.6 g/day of fish oil did not favorably modulate parameters of inflammation or immune senescence in HIV-infected adults. Future studies should test agents that directly target mechanisms that underlie HIV-related inflammation to determine whether reducing inflammation can reverse immunosenescence.
- Subjects
UNITED States; FISH oils; HIV infection complications; AGING; BIOMARKERS; CHI-squared test; CYTOKINES; DEMOGRAPHY; ETHNIC groups; IMMUNE system; INFLAMMATION; OMEGA-3 fatty acids; RESEARCH funding; RNA; T cells; HUMAN research subjects; PATIENT selection; DATA analysis software; ADVERSE health care events; MANN Whitney U Test; THERAPEUTICS
- Publication
Journal of Alternative & Complementary Medicine, 2018, Vol 24, Issue 7, p709
- ISSN
1075-5535
- Publication type
Article
- DOI
10.1089/acm.2017.0222