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- Title
Human peripheral blood and bone marrow Epstein-Barr virus-specific T-cell repertoire in latent infection reveals distinct memory T-cell subsets.
- Authors
Guerreiro, Manuel; Na, Il-Kang; Letsch, Anne; Haase, Doreen; Bauer, Sandra; Meisel, Christian; Roemhild, Andy; Reinke, Petra; Volk, Hans-Dieter; Scheibenbogen, Carmen
- Abstract
EBV infection leads to life-long viral persistence. Although EBV infection can result in chronic disease and malignant transformation, most carriers remain disease-free as a result of effective control by T cells. EBV-specific IFN-γ-producing T cells could be demonstrated in acute and chronic infection as well as during latency. Recent studies, however, provide evidence that assessing IFN-γ alone is insufficient to assess the quantity and quality of a T-cell response. Using overlapping peptide pools of latent EBV nuclear antigen 1 and lytic BZLF-1 protein and multicolor flow cytometry, we demonstrate that the majority of ex vivo EBV-reactive T cells in healthy virus carriers are indeed IL-2- and/or TNF-producing memory cells, the latter being significantly more frequent in BM. After in vitro expansion, a substantial number of EBV-specific CD4
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 6, p1566
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200940000