We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Moment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions.
- Authors
Michelmann, Sebastian; Price, Amy R.; Aubrey, Bobbi; Strauss, Camilla K.; Doyle, Werner K.; Friedman, Daniel; Dugan, Patricia C.; Devinsky, Orrin; Devore, Sasha; Flinker, Adeen; Hasson, Uri; Norman, Kenneth A.
- Abstract
Humans form lasting memories of stimuli that were only encountered once. This naturally occurs when listening to a story, however it remains unclear how and when memories are stored and retrieved during story-listening. Here, we first confirm in behavioral experiments that participants can learn about the structure of a story after a single exposure and are able to recall upcoming words when the story is presented again. We then track mnemonic information in high frequency activity (70–200 Hz) as patients undergoing electrocorticographic recordings listen twice to the same story. We demonstrate predictive recall of upcoming information through neural responses in auditory processing regions. This neural measure correlates with behavioral measures of event segmentation and learning. Event boundaries are linked to information flow from cortex to hippocampus. When listening for a second time, information flow from hippocampus to cortex precedes moments of predictive recall. These results provide insight on a fine-grained temporal scale into how episodic memory encoding and retrieval work under naturalistic conditions. When listening to a story, humans learn about its structure and content. Here the authors reveal the neural processes behind episodic memory and predictive recall at a fine temporal scale in this naturalistic setting
- Subjects
AUDITORY perception; EPISODIC memory; ARTIFICIAL satellite tracking; HIPPOCAMPUS (Brain)
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-25376-y