We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.
- Authors
Wang, Chi; Liu, Hui; Li, Kun; Wu, Zhen-Zhen; Wu, Chen; Yu, Jing-Ying; Gong, Qian; Fang, Ping; Wang, Xing-Xing; Duan, Shu-Min; Wang, Hao; Gu, Yan; Hu, Ji; Pan, Bing-Xing; Schmidt, Mathias V.; Liu, Yi-Jun; Wang, Xiao-Dong
- Abstract
Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. Here, we report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and increases the presynaptic input from the lateral entorhinal cortex (LEC), which is reciprocally connected with the primary somatosensory cortex (S1), to tactile experience-activated DG neurons. Chemogenetic activation of tactile experience-tagged dorsal and ventral DG neurons enhances memory and reduces anxiety respectively, whereas inactivation of these neurons or S1-innervated LEC neurons abolishes the beneficial effects of tactile enrichment. Moreover, adulthood tactile enrichment attenuates early-life stress-induced memory deficits and anxiety-related behavior. Our findings demonstrate that enriched tactile experience retunes the pathway from S1 to DG and enhances DG neuronal plasticity to modulate cognition and emotion. Touch can positively modulate cognitive performance and emotional response. Here the authors demonstrate that enriched tactile experience improves memory and reduces anxiety in adult mice by remodelling the pathway from the primary somatosensory cortex to the dentate gyrus.
- Subjects
GRANULE cells; ENTORHINAL cortex; ANXIETY; DENTATE gyrus; SOMATOSENSORY cortex; NEUROPLASTICITY; MEMORY
- Publication
Nature Communications, 2020, Vol 11, Issue 1, pN.PAG
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-19874-8