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- Title
Association between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUID prospective cohort study.
- Authors
Helmer, C.; Peuchant, E.; Letenneur, L.; Bourdel-Marchasson, I.; Larrieu, S.; Dartigues, J. F.; Dubourg, L.; Thomas, M-J; Barberger-Gateau, P.
- Abstract
OBJECTIVE:: To analyse the relation between antioxidant vitamins A, E, and malondialdehyde (MDA) lipoperoxidation product plasma concentrations with incident dementia. DESIGN:: A nested case-control within the PAQUID (Personnes Agées QUID) cohort. SETTING:: The PAQUID population-based prospective cohort in southwestern France. SUBJECTS:: Among 626 subjects with blood collection at baseline, 46 developed a dementia during the follow-up and were considered to be cases. Each case was matched (on age and sex) to three controls. RESULTS:: Plasma vitamin E concentrations were lower among cases (mean value at 22.62?µmol/l (s.d.: 7.38) vs 24.99 (s.d.: 6.73 among controls). The same trend was observed for vitamin A concentrations, but the difference was not significant. On the contrary, MDA concentrations tended to be higher (mean value 1.35?µmol/l (s.d.: 0.53) vs 1.23 (s.d.: 0.44)) among cases. In logistic regression models, plasma values were split into tertiles. Adjusted for confounders, the risk of dementia was significantly increased in the lowest vitamin E tertile (=21.0?µmol/l) (OR=3.12, P=0.033) compared to the highest one (=25.5?µmol/l). The risk of Alzheimer's disease was also increased, with borderline significance (OR=3.06, P=0.053). Risks associated with vitamin A were nonsignificant. Similarly, there was a trend to an increased risk of dementia in the highest tertile of MDA (OR=1.67, P=0.31). CONCLUSIONS:: These results suggest that subjects with low plasma vitamin E concentrations are at a higher risk of developing a dementia in subsequent years.European Journal of Clinical Nutrition (2003) 57, 1555-1561. doi:10.1038/sj.ejcn.1601724
- Subjects
HUNTINGTON disease; ISOPENTENOIDS; DEMENTIA; ANTIOXIDANTS; NEUROBEHAVIORAL disorders
- Publication
European Journal of Clinical Nutrition, 2003, Vol 57, Issue 12, p1555
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/sj.ejcn.1601724