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- Title
Avaliação do papel do sistema canabidiol em um modelo de lesão renal por isquemia/reperfusão em animais.
- Authors
Zon Soares, Rodrigo; Vuolo, Francieli; Mozena Dall'Igna, Dhébora; Michels, Monique; de Souza Crippa, José Alexandre; Cecílio Hallak, Jaime Eduardo; Waldo Zuardi, Antonio; Dal-Pizzol, Felipe
- Abstract
Objective: This work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model. Methods: Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion. Results: Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated by cannabidiol treatment. Additionally, cannabidiol was able to decrease lipid and protein oxidative damage, but not the nitrite/nitrate levels. Kidney injury after ischemia/reperfusion seemed to be independent of the cannabidiol receptor 1 and cannabidiol receptor 2 (CB1 and CB2) expression levels, as there was no significant increase in these receptors after reperfusion. Conclusion: The cannabidiol treatment had a protective effect against inflammation and oxidative damage in the kidney ischemia/reperfusion model. These effects seemed to be independent of CB1/CB2 receptor activation.
- Publication
Revista Brasileira de Terapia Intensiva, 2015, Vol 27, Issue 4, p383
- ISSN
0103-507X
- Publication type
Article
- DOI
10.5935/0103-507X.20150064