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- Title
N-acetylcysteine and deferoxamine protect against acute renal failure induced by ischemia/reperfusion in rats.
- Authors
Meister Bernardi, Roberto; Constantino, Larissa; Albino Machado, Roberta; Vuolo, Francieli; Budni, Patricia; Ritter, Cristiane; Dal-Pizzol, Felipe
- Abstract
Objective: Antioxidants are widely used in animal models to prevent renal injury after ischemia/reperfusion, but it is unknown if the benefits of antioxidants are additive. In this study, we aimed to investigate the protective effects of N-acetylcysteine plus deferoxamine in an animal model of kidney ischemia/reperfusion injury. Methods: Bilateral kidney ischemia was mastintained for 45 minutes. N-acetylcysteine, deferoxamine or both were administered into the aorta above the renal arteries immediately prior to induction of ischemia. Five rats from each group were sacrificed 1, 6 or 12 hours after reperfusion for the determination of blood creatinine, kidney oxidative damage parameters and myeloperoxidase activity. Results: The combination of N-acetylcysteine and deferoxamine, but not their isolated use, prevented the increase in creatinine after ischemia/ reperfusion. This prevention was followed by a consistent decrease in myeloperoxidase activity and oxidative damage parameters both in the kidney cortex and medulla. Conclusion: Treatment with N-acetylcysteine and deferoxamine was superior to the isolated use of either compound in an animal model of kidney ischemia/reperfusion.
- Subjects
ACUTE kidney failure prevention; ACETYLCYSTEINE; DEFEROXAMINE; ANIMAL models of ischemia; THERAPEUTIC use of antioxidants
- Publication
Revista Brasileira de Terapia Intensiva, 2012, Vol 24, Issue 3, p219
- ISSN
0103-507X
- Publication type
Article