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- Title
A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing.
- Authors
Chiu, Elliott S.; Hoover, Edward A.; VandeWoude, Sue
- Abstract
Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma. The original research conducted on FeLV employed classical virological techniques. As methods have evolved to allow FeLV genetic characterization, investigators have continued to unravel the molecular pathology associated with this fascinating agent. In this review, we discuss how FeLV classification, transmission, and disease-inducing potential have been defined sequentially by viral interference assays, Sanger sequencing, PCR, and next-generation sequencing. In particular, we highlight the influences of endogenous FeLV and host genetics that represent FeLV research opportunities on the near horizon.
- Subjects
FELINE leukemia virus; NUCLEOTIDE sequencing; POLYMERASE chain reaction; VIRAL transmission; VIRAL genomes
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 1, p29
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10010029