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- Title
Stress Granules in the Viral Replication Cycle.
- Authors
Montero, Hilda; Trujillo-Alonso, Vicenta
- Abstract
As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R (PKR). PKR phosphorylates the a subunit of eukaryotic translation initiation factor 2 (eIF2a), which in turn results in global protein synthesis inhibition and formation of stress granules (SGs). Recent studies have shown that SGs can interfere with the replicative cycle of certain viruses. This review addresses how viruses have evolved different control strategies at the SG level to ensure an efficient replication cycle during the cellular stress response triggered by the viral infection.
- Subjects
INTRACELLULAR pathogens; VIRAL replication; IMMUNE response; DOUBLE-stranded RNA; PROTEIN kinases; PROTEIN synthesis; VIRUS diseases
- Publication
Viruses (1999-4915), 2011, Vol 3, Issue 11, p2328
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v3112328