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Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volunteers.
Published in:
Journal of Personalized Medicine, 2021, v. 11, n. 6, p. 457, doi. 10.3390/jpm11060457
By:
- Li, Xue-Qing;
- Thelingwani, Roslyn Stella;
- Bertilsson, Leif;
- Diczfalusy, Ulf;
- Andersson, Tommy B.;
- Masimirembwa, Collen
Publication type:
Article
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.
Published in:
Thrombosis, 2016, p. 1, doi. 10.1155/2016/8648356
By:
- Ghosheh, Nidal;
- Olsson, Björn;
- Edsbagge, Josefina;
- Küppers-Munther, Barbara;
- Van Giezen, Mariska;
- Asplund, Annika;
- Andersson, Tommy B.;
- Björquist, Petter;
- Carén, Helena;
- Simonsson, Stina;
- Sartipy, Peter;
- Synnergren, Jane
Publication type:
Article
Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.
Published in:
Biotechnology & Bioengineering, 2012, v. 109, n. 12, p. 3172, doi. 10.1002/bit.24573
By:
- Hoffmann, Stefan A.;
- Müller-Vieira, Ursula;
- Biemel, Klaus;
- Knobeloch, Daniel;
- Heydel, Sandra;
- Lübberstedt, Marc;
- Nüssler, Andreas K.;
- Andersson, Tommy B.;
- Gerlach, Jörg C.;
- Zeilinger, Katrin
Publication type:
Article
Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.
Published in:
British Journal of Clinical Pharmacology, 2022, v. 88, n. 9, p. 4121, doi. 10.1111/bcp.15349
By:
- Kvitne, Kine Eide;
- Krogstad, Veronica;
- Wegler, Christine;
- Johnson, Line Kristin;
- Kringen, Marianne K.;
- Hovd, Markus Herberg;
- Hertel, Jens K.;
- Heijer, Maria;
- Sandbu, Rune;
- Skovlund, Eva;
- Artursson, Per;
- Karlsson, Cecilia;
- Andersson, Shalini;
- Andersson, Tommy B.;
- Hjelmesæth, Jøran;
- Åsberg, Anders;
- Jansson‐Löfmark, Rasmus;
- Christensen, Hege;
- Robertsen, Ida
Publication type:
Article
4β-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.
Published in:
British Journal of Clinical Pharmacology, 2009, v. 67, n. 1, p. 38, doi. 10.1111/j.1365-2125.2008.03309.x
By:
- Diczfalusy, Ulf;
- Kanebratt, Kajsa P.;
- Bredberg, Eva;
- Andersson, Tommy B.;
- Böttiger, Ylva;
- Bertilsson, Leif
Publication type:
Article
Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research.
Published in:
PLoS Computational Biology, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.pcbi.1010587
By:
- Casas, Belén;
- Vilén, Liisa;
- Bauer, Sophie;
- Kanebratt, Kajsa P.;
- Wennberg Huldt, Charlotte;
- Magnusson, Lisa;
- Marx, Uwe;
- Andersson, Tommy B.;
- Gennemark, Peter;
- Cedersund, Gunnar
Publication type:
Article
The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47737-w
By:
- Prill, Sebastian;
- Caddeo, Andrea;
- Baselli, Guido;
- Jamialahmadi, Oveis;
- Dongiovanni, Paola;
- Rametta, Raffaela;
- Kanebratt, Kajsa P.;
- Pujia, Arturo;
- Pingitore, Piero;
- Mancina, Rosellina Margherita;
- Lindén, Daniel;
- Whatling, Carl;
- Janefeldt, Annika;
- Kozyra, Mikael;
- Ingelman-Sundberg, Magnus;
- Valenti, Luca;
- Andersson, Tommy B.;
- Romeo, Stefano
Publication type:
Article
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.
Published in:
European Journal of Clinical Pharmacology, 2022, v. 78, n. 8, p. 1289, doi. 10.1007/s00228-022-03336-9
By:
- Eide Kvitne, Kine;
- Hole, Kristine;
- Krogstad, Veronica;
- Wollmann, Birgit Malene;
- Wegler, Christine;
- Johnson, Line K.;
- Hertel, Jens K.;
- Artursson, Per;
- Karlsson, Cecilia;
- Andersson, Shalini;
- Andersson, Tommy B.;
- Sandbu, Rune;
- Hjelmesæth, Jøran;
- Skovlund, Eva;
- Christensen, Hege;
- Jansson-Löfmark, Rasmus;
- Åsberg, Anders;
- Molden, Espen;
- Robertsen, Ida
Publication type:
Article
Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system.
Published in:
Communications Biology, 2024, p. 1, doi. 10.1038/s42003-024-06514-w
By:
- Rigal, Sophie;
- Casas, Belén;
- Kanebratt, Kajsa P.;
- Wennberg Huldt, Charlotte;
- Magnusson, Lisa U.;
- Müllers, Erik;
- Karlsson, Fredrik;
- Clausen, Maryam;
- Hansson, Sara F.;
- Leonard, Louise;
- Cairns, Jonathan;
- Jansson Löfmark, Rasmus;
- Ämmälä, Carina;
- Marx, Uwe;
- Gennemark, Peter;
- Cedersund, Gunnar;
- Andersson, Tommy B.;
- Vilén, Liisa K.
Publication type:
Article
Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 5, p. 1142, doi. 10.1002/cpt.2558
By:
- Wegler, Christine;
- Wiśniewski, Jacek R.;
- Robertsen, Ida;
- Christensen, Hege;
- Kristoffer Hertel, Jens;
- Hjelmesæth, Jøran;
- Jansson‐Löfmark, Rasmus;
- Åsberg, Anders;
- Andersson, Tommy B.;
- Artursson, Per
Publication type:
Article
Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight.
Published in:
Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 3, p. 762, doi. 10.1002/cpt.2056
By:
- Wegler, Christine;
- Prieto Garcia, Luna;
- Klinting, Signe;
- Robertsen, Ida;
- Wiśniewski, Jacek R.;
- Hjelmesæth, Jøran;
- Åsberg, Anders;
- Jansson‐Löfmark, Rasmus;
- Andersson, Tommy B.;
- Artursson, Per
Publication type:
Article
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 844, doi. 10.1002/cpt.1860
By:
- Hendriks, Delilah F.G.;
- Vorrink, Sabine U.;
- Smutny, Tomas;
- Sim, Sarah C.;
- Nordling, Åsa;
- Ullah, Shahid;
- Kumondai, Masaki;
- Jones, Barry C.;
- Johansson, Inger;
- Andersson, Tommy B.;
- Lauschke, Volker M.;
- Ingelman‐Sundberg, Magnus
Publication type:
Article
Identification of human cytochrome P<sub>450</sub>s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data.
Published in:
European Journal of Clinical Pharmacology, 2003, v. 59, n. 5/6, p. 429, doi. 10.1007/s00228-003-0636-9
By:
- Xue-Qing Li;
- Björkman, Anders;
- Andersson, Tommy B.;
- Gustafsson, Lars L.;
- Masimirembwa, Collen M.
Publication type:
Article
Cytochrome P<sub>450</sub> 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.
Published in:
European Journal of Clinical Pharmacology, 2002, v. 58, n. 8, p. 537, doi. 10.1007/s00228-002-0512-z
By:
- Bapiro, Tashinga E.;
- Andersson, Tommy B.;
- Otter, Charlotta;
- Hasler, Julia A.;
- Masimirembwa, Collen M.
Publication type:
Article
Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s.
Published in:
2018
By:
- Lindmark, Bo;
- Lundahl, Anna;
- Kanebratt, Kajsa P;
- Andersson, Tommy B;
- Isin, Emre M
Publication type:
journal article
Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions.
Published in:
2003
By:
- Bredberg, Eva;
- Andersson, Tommy B.;
- Frison, Lars;
- Thuresson, Annelie;
- Johansson, Susanne;
- Eriksson-Lepkowska, Maria;
- Larsson, Marita;
- Eriksson, Ulf G.
Publication type:
journal article
Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges.
Published in:
2003
By:
- Masimirembwa, Collen M.;
- Bredberg, Ulf;
- Andersson, Tommy B.
Publication type:
journal article
PhRMA White Paper on ADME Pharmacogenomics.
Published in:
Journal of Clinical Pharmacology, 2008, v. 48, n. 7, p. 849, doi. 10.1177/0091270008319329
By:
- Williams, J. Andrew;
- Andersson, Tommy;
- Andersson, Tommy B.;
- Blanchard, Rebecca;
- Behm, Martin Otto;
- Cohen, Nadine;
- Edeki, Timi;
- Franc, Monique;
- Hiligren, Kathleen M.;
- Johnson, Keith J.;
- Katz, David A.;
- Milton, Mark N.;
- Murray, Bernard P.;
- Polli, Joseph W.;
- Ricci, Deb;
- Shipley, Lisa A.;
- Vangala, Subrahmanyam;
- Wrighton, Steven A.
Publication type:
Article
Biology-Inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development.
Published in:
Altex, 2020, v. 37, n. 3, p. 365, doi. 10.14573/altex.2001241
By:
- Marx, Uwe;
- Akabane, Takafumi;
- Andersson, Tommy B.;
- Baker, Elizabeth;
- Beilmann, Mario;
- Beken, Sonja;
- Brendler-Schwaab, Susanne;
- Cirit, Murat;
- David, Rhiannon;
- Dehne, Eva-Maria;
- Durieux, Isabell;
- Ewart, Lorna;
- Fitzpatrick, Suzanne C.;
- Frey, Olivier;
- Fuchs, Florian;
- Griffith, Linda G.;
- Hamilton, Geraldine A.;
- Hartung, Thomas;
- Hoeng, Julia;
- Hogberg, Helena
Publication type:
Article
Biology-Inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing.
Published in:
Altex, 2016, v. 33, n. 3, p. 272, doi. 10.14573/altex.1603161
By:
- Marx, Uwe;
- Andersson, Tommy B.;
- Bahinski, Anthony;
- Beilmann, Mario;
- Beken, Sonja;
- Cassee, Flemming R.;
- Cirit, Murat;
- Daneshian, Mardas;
- Fitzpatrick, Susan;
- Frey, Olivier;
- Gaertner, Claudia;
- Giese, Christoph;
- Griffith, Linda;
- Hartung, Thomas;
- Heringa, Minne B.;
- Hoeng, Julia;
- de Jong, Wim H.;
- Kojima, Hajime;
- Kuehnl, Jochen;
- Leist, Marcel
Publication type:
Article
Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.
Published in:
Journal of Tissue Engineering & Regenerative Medicine, 2015, v. 9, n. 9, p. 1017, doi. 10.1002/term.1652
By:
- Lübberstedt, Marc;
- Müller‐Vieira, Ursula;
- Biemel, Klaus M.;
- Darnell, Malin;
- Hoffmann, Stefan A;
- Knöspel, Fanny;
- Wönne, Eva C;
- Knobeloch, Daniel;
- Nüssler, Andreas K;
- Gerlach, Jörg C;
- Andersson, Tommy B;
- Zeilinger, Katrin
Publication type:
Article
Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.
Published in:
Stem Cells International, 2016, p. 1, doi. 10.1155/2016/8648356
By:
- Ghosheh, Nidal;
- Olsson, Björn;
- Edsbagge, Josefina;
- Küppers-Munther, Barbara;
- Van Giezen, Mariska;
- Asplund, Annika;
- Andersson, Tommy B.;
- Björquist, Petter;
- Carén, Helena;
- Simonsson, Stina;
- Sartipy, Peter;
- Synnergren, Jane
Publication type:
Article
Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial.
Published in:
CTS: Clinical & Translational Science, 2022, v. 15, n. 1, p. 221, doi. 10.1111/cts.13142
By:
- Kvitne, Kine Eide;
- Robertsen, Ida;
- Skovlund, Eva;
- Christensen, Hege;
- Krogstad, Veronica;
- Wegler, Christine;
- Angeles, Philip Carlo;
- Wollmann, Birgit Malene;
- Hole, Kristine;
- Johnson, Line Kristin;
- Sandbu, Rune;
- Artursson, Per;
- Karlsson, Cecilia;
- Andersson, Shalini;
- Andersson, Tommy B.;
- Hjelmesæth, Jøran;
- Jansson‐Löfmark, Rasmus;
- Åsberg, Anders
Publication type:
Article
Toward Preclinical Predictive Drug Testing for Metabolism and Hepatotoxicity by Using In Vitro Models Derived from Human Embryonic Stem Cells and Human Cell Lines--A Report on the Vitrocellomics EU-project.
Published in:
Alternatives to Laboratory Animals, 2011, v. 39, n. 2, p. 147, doi. 10.1177/026119291103900210
By:
- Mandenius, Carl-Fredrik;
- Andersson, Tommy B.;
- Alves, Paula M.;
- Batzl-Hartmann, Christine;
- Björquist,, Petter;
- Carrondo, Manuel J. T.;
- Chesne, Christophe;
- Coecke, Sandra;
- Edsbagge, Josefina;
- Fredriksson, J. Magnus;
- Gerlach, Jörg C.;
- Heinzle, Elmar;
- Ingelman-Sundberg, Magnus;
- Johansson, Inger;
- Küppers-Munther, Barbara;
- Müller-Vieira,, Ursula;
- Noor, Fozia;
- Zeilinger, Katrin
Publication type:
Article
Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2018, v. 123, p. 42, doi. 10.1111/bcpt.13004
By:
- Hakkola, Jukka;
- Bernasconi, Camilla;
- Coecke, Sandra;
- Richert, Lysiane;
- Andersson, Tommy B.;
- Pelkonen, Olavi
Publication type:
Article
Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2017, v. 121, n. 4, p. 234, doi. 10.1111/bcpt.12804
By:
- Andersson, Tommy B.
Publication type:
Article
Hepatic Disposition of Ximelagatran and Its Metabolites in Pig; Prediction of the Impact of Membrane Transporters Through a Simple Disposition Model.
Published in:
Pharmaceutical Research, 2010, v. 27, n. 4, p. 597, doi. 10.1007/s11095-009-0016-y
By:
- Sjögren, Erik;
- Bredberg, Ulf;
- Allard, Erik;
- Arvidsson, Björn;
- Bergquist, Jonas;
- Andersson, Tommy B.;
- Lennernäs, Hans
Publication type:
Article

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