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- Title
A New Flavonol From Saussurea involucrata With Anti-Inflammatory Activity.
- Authors
Sheng Pan; Zi-Guan Zhu
- Abstract
A new flavonol named 6-(2",3"-epoxy-3"-methylbutyl)-resokaempferol (1), together with five known compounds (2-6) were isolated from the EtOAc-soluble extract of the aerial part of Saussurea involucrata. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for their anti-inflammatory effects by measuring the production of nitric oxide (NO) and TNF-α in vitro. Among them, compound 1 showed potential inhibitory activity on the production of NO and TNF-α in LPS-induced RAW 264.7 cells with IC50 values of 48.0 ± 1.5 and 41.4 ± 1.7 µM, respectively.
- Subjects
FLAVONOLS; SAUSSUREA; ANTI-inflammatory agents; SPECTROMETRY; NITRIC oxide
- Publication
Natural Product Communications, 2021, Vol 16, Issue 5, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X211007638