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- Title
Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O<sub>2</sub><sup>−</sup> Production.
- Authors
Franceschelli, Sara; Pesce, Mirko; Ferrone, Alessio; De Lutiis, Maria Anna; Patruno, Antonia; Grilli, Alfredo; Felaco, Mario; Speranza, Lorenza
- Abstract
Recently, astaxanthin (ASTA) studies have focused on several biological functions such as radical scavenging, singlet oxygen quenching, anti-carcinogenesis, anti-diabetic, anti-obesity, anti-inflammatory, anti-melanogenesis, and immune enhancement activities. In this study, we investigated the potential role protective of ASTA, an antioxidant marine carotenoid, in restoring physiological conditions in U937 cells stimulated with LPS (10 µg/ml). Our results show that pre-treatment with ASTA (10 µM) for 1 h attenuates the LPS-induced toxicity and ROS production. The beneficial effect of ASTA is associated with a reduction intracellular O2− production by restoring the antioxidant network activity of superoxide dismutase (SOD) and catalase (CAT), which influence HO-1 expression and activity by inhibiting nuclear translocation of Nrf2. We accordingly hypothesize that ASTA has therapeutic properties protecting U937 cells from LPS-induced inflammatory and oxidative stress.
- Subjects
ASTAXANTHIN; REACTIVE oxygen species; SUPEROXIDE dismutase; OXIDATIVE stress; LIPOPOLYSACCHARIDES; HYPOGLYCEMIC agents; ANTIOBESITY agents; CELLULAR signal transduction
- Publication
PLoS ONE, 2014, Vol 9, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0088359