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- Title
Impact of blood perilipin A levels on obesity and metabolic health.
- Authors
Ofori, Emmanuel K.; Letsu, Bright Selorm; Amponsah, Seth K.; Ahenkorah, John; Crabbe, Sandra; Kwao-Zigah, Genevieve; Oppong, Sylvester Y.; Diaba-Nuhoho, Patrick; Amanquah, Seth D.
- Abstract
Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health. Results: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = − 0.32, − 0.37, − 0.40, − 0.45, − 0.33 and − 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35–11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.
- Subjects
PERILIPIN; ADIPOSE tissues; FAT; OBESITY; OVERWEIGHT persons; ODDS ratio
- Publication
BMC Research Notes, 2022, Vol 15, Issue 1, p1
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-022-06261-3