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- Title
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition.
- Authors
Morel, Anne-Pierre; Lièvre, Marjory; Thomas, Clémence; Hinkal, George; Ansieau, Stéphane; Puisieux, Alain
- Abstract
Recently, two novel concepts have emerged in cancer biology: the role of so-called ''cancer stem cells'' in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of ''cancer stem cells'' can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.
- Subjects
CANCER education; CANCER invasiveness; STEM cells; BREAST cancer; EPITHELIAL cells; CANCER cells; METASTASIS; TUMORS; MESENCHYMAL stem cells
- Publication
PLoS ONE, 2008, Vol 3, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0002888