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- Title
The effects of extraction method on recovery rutin from Calendula offcinalis L. (Asteraceae).
- Authors
Martins, Frederico Severino; Conceição, Edemilson Cardoso da; Bandeira, Elane Sousa; Carréra Silva Junior, José Otávio; Ribeiro Costa, Roseane Maria
- Abstract
Background: Calendula officinalis L. (Asteraceae) is a Mediterranean specie, but in Europe and America it is cultivated for ornamental or medicinal purposes. This species is widely used for presenting activities, antiinflammatory antibacterial and antioxidant. However the therapeutic action is linked to the amount of assets of the extracted raw material. The extraction method of bioactive compounds is an important step in the manufacturing of herbal medicines, because secondary metabolites with therapeutic potential are usually found in small quantities in plant materials. Objective: Due the medical and commercial importance of C. officinalis, this study aimed to evaluate the impact of the extraction method on the quality of herbal extract and optimize the extraction of rutin from C. officinalis. Materials and Methods: The extraction of rutin was performed by ultrasound and shaker and the optimized conditions were determined by response surface methodology. Results: The results of ultrasound extraction assisted (UEA) and maceration dynamic (MD) showed that rutin yield ranged from 0.218 to 2.28% (w/w) when extract by ultrasound and 0.1-1.44% by MD. The optimal extraction condition for rutin (2.48% to UEA or 1.46% to MD) from C. officinalis by UEA or MD were a 19-22 min extraction, ethanol: water ratio of 35-40% and 0.05-0.056 mg/mL to raw material: solvent ratio. Conclusion: The UEA is more efficient to extraction rutin.
- Subjects
EXTRACTION (Chemistry); RUTIN; ANTIOXIDANTS; FACTORIAL experiment designs; RESPONSE surfaces (Statistics)
- Publication
Pharmacognosy Magazine, 2014, Vol 10, Issue S3, pS569
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/0973-1296.139785