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- Title
Contribution of cocaine-related cues to concurrent monetary choice in humans.
- Authors
Strickland, Justin C.; Marks, Katherine R.; Beckmann, Joshua S.; Lile, Joshua A.; Rush, Craig R.; Stoops, William W.
- Abstract
Rationale: Theoretical accounts highlight the importance of drug-related cues for the development and persistence of drug-taking behavior. Few studies have evaluated the ability of spatially contiguous drug cues to bias decisions between two concurrently presented non-drug reinforcers.Objective: Evaluate the contribution of spatially contiguous cocaine cues to choice between two concurrently presented monetary reinforcersMethods: Participants with cocaine use disorder completed a cued concurrent choice task. Two cues (one cocaine and one control image) were presented side-by-side followed by concurrent monetary offers below each image. Concurrent choice was measured for cocaine-side advantageous, equal, and disadvantageous concurrent monetary offers. The primary dependent measure was bias for selecting cocaine-cued monetary reinforcers. Three experiments tested selectivity of cocaine-cued bias in individuals with a cocaine use history (Experiment 1), replication when including additional control trials (Experiment 2), and a potential attentional mechanism evaluated using eye-tracking technology (Experiment 3).Results: Significant and robust cocaine-cued bias at equal monetary value was observed in three experiments (mean percent choice = 65-77%) and higher Drug Abuse Screening Test (DAST) scores were associated with greater cocaine-choice bias. These experiments demonstrated that cocaine-cued bias was (1) selective to individuals with a cocaine use history, (2) specific to trials involving a cocaine cue, and (3) partially associated with attentional bias.Conclusions: These experiments provide evidence that drug-related cues can influence choice and potentially promote maladaptive decision making during concurrent choice events. Future research evaluating prospective associations of drug-cued bias with drug-associated behaviors will help reveal the clinical relevance for substance use disorder.
- Subjects
COCAINE-induced disorders; PROMPTS (Psychology); ATTENTIONAL bias; COCAINE abuse; DECISION making
- Publication
Psychopharmacology, 2018, Vol 235, Issue 10, p2871
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-018-4978-5