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- Title
Auditory Detection Thresholds and Cochlear Resistivity Differ Between Pediatric Cochlear Implant Listeners With Enlarged Vestibular Aqueduct and Those With Connexin-26 Mutations.
- Authors
Jahn, Kelly N.; Bergan, Molly D.; Arenberg, Julie G.
- Abstract
Purpose: The goal of this study was to evaluate differences in the electrode--neuron interface as a function of hearing loss etiology in pediatric cochlear implant (CI) listeners with enlarged vestibular aqueduct (EVA) syndrome and in those with autosomal recessive connexin-26 mutations (DFNB1). Method: Fifteen implanted ears (9 participants, 5 ears with EVA, 10 ears with DFNB1) were assessed. Single-channel auditory detection thresholds were measured using broad and spatially focused electrode configurations (steered quadrupolar; focusing coefficients = 0 and 0.9). Cochlear resistivity estimates were obtained via electrode impedances and electrical field imaging. Between-group differences were evaluated using linear mixed-effects models. Results: Children with EVA had significantly higher auditory detection thresholds than children with DFNB1, irrespective of electrode configuration. Between-group differences in thresholds were more pronounced on apical electrodes than on basal electrodes. In the apex, electrode impedances and electrical field imaging values were higher for children with EVA than for those with DFNB1. Conclusions: The electrode--neuron interface differs between pediatric CI listeners with DFNB1 and those with EVA. It is possible that optimal clinical interventions may depend, in part, on hearing loss etiology. Future investigations with large samples should investigate individualized CI programming strategies for listeners with EVA and DFNB1.
- Subjects
COCHLEA physiology; CHROMOSOME abnormalities; COCHLEAR implants; ELECTRODES; HEARING disorders; HEARING levels; BIOELECTRIC impedance; RESEARCH methodology; MEDICAL equipment calibration; GENETIC mutation; REGRESSION analysis; RESEARCH; RESEARCH funding; CONNEXINS; CAUSAL models; DATA analysis software; DESCRIPTIVE statistics; VESTIBULAR aqueduct
- Publication
American Journal of Audiology, 2020, Vol 29, Issue 1, p23
- ISSN
1059-0889
- Publication type
Article
- DOI
10.1044/2019_AJA-19-00054