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- Title
The role of non-receptor protein tyrosine kinases in the excitotoxicity induced by the overactivation of NMDA receptors.
- Authors
Sun, Yongjun; Chen, You; Zhan, Liying; Zhang, Linan; Hu, Jie; Gao, Zibin
- Abstract
Protein tyrosine phosphorylation is one of the primary modes of regulation of N-methyl- d-aspartate (NMDA) receptors. The non-receptor tyrosine kinases are one of the two types of protein tyrosine kinases that are involved in this process. The overactivation of NMDA receptors is a primary reason for neuron death following cerebral ischemia. Many studies have illustrated the important role of non-receptor tyrosine kinases in ischemia insults. This review introduces the roles of Src, Fyn, focal adhesion kinase, and proline-rich tyrosine kinase 2 in the excitotoxicity induced by the overactivation of NMDA receptors following cerebral ischemia.
- Publication
Reviews in the Neurosciences, 2016, Vol 27, Issue 3, p283
- ISSN
0334-1763
- Publication type
Article
- DOI
10.1515/revneuro-2015-0037