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- Title
Inflammatory and Nutritional Biomarkers in Patients With Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Radiation Therapy.
- Authors
Chun Hou Huang; Bee Song Chang; Tai-Chu Peng; Yun-Hsin Peng
- Abstract
OBJECTIVES: To investigate the relationship between pretreatment inflammatory and nutritional biomarkers in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy and radiation therapy (nCRT). SAMPLE & SETTING: 213 patients with newly diagnosed stage II-III ESCC who received nCRT at an academic hospital in Taiwan. METHODS & VARIABLES: Electronic health record data were used. Records on inflammatory and nutritional biomarkers and clinical outcomes were extracted. Logistic regression analysis was used to predict treatment-related adverse events, Cox regression was used for survival outcomes, and receiver operating characteristic curve analysis was used to determine optimal cutoff values. RESULTS: There was a significant association between low prognostic nutritional index (PNI) and nCRT toxicities and survival. Advanced cancer stage, high platelet-to-lymphocyte ratio, and occurrence of pneumonia/infection were linked to survival outcomes. IMPLICATIONS FOR NURSING: PNI shows promise in predicting prognosis, helps identify high-risk patients, and enables nurses to apply tailored interventions.
- Subjects
TAIWAN; TREATMENT of esophageal cancer; SQUAMOUS cell carcinoma; STATISTICAL correlation; DRUG toxicity; ACADEMIC medical centers; RECEIVER operating characteristic curves; RESEARCH funding; RADIOTHERAPY; LOGISTIC regression analysis; NUTRITIONAL assessment; MULTIPLE regression analysis; TUMOR markers; CANCER patients; RETROSPECTIVE studies; SYMPTOMS; DESCRIPTIVE statistics; ADJUVANT chemotherapy; PLATELET lymphocyte ratio; COMBINED modality therapy; ELECTRONIC health records; MEDICAL records; ACQUISITION of data; RESEARCH; STATISTICS; INFLAMMATION; ADVERSE health care events; PROGRESSION-free survival; NUTRITION; PROPORTIONAL hazards models; ESOPHAGEAL cancer; OVERALL survival
- Publication
Oncology Nursing Forum, 2024, Vol 51, Issue 2, p177
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/24.ONF.177-192