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- Title
Model that predicted death or disabilities in premature infants was valid at seven years of age.
- Authors
Piris Borregas, Salvador; Torres Valdivieso, María José; Martín‐Arriscado, Cristina; Cruz Bértolo, Javier; Sierra García, Purificación; Pallás Alonso, Carmen Rosa; Martín-Arriscado, Cristina; de la Cruz Bértolo, Javier
- Abstract
<bold>Aim: </bold>Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age.<bold>Methods: </bold>A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity, and the effect that the combination of morbidities had on the seven-year outcomes. The analysis was performed on the total cohort from 1991 to 2008 and on two subcohorts from 1991 to 1998 and 1999 to 2008.<bold>Results: </bold>A total of 1001 children were included with a mean birth weight of 922 ± 208 g. Severe ROP was strongly associated with poor neurodevelopment, with an odds ratio (OR) 3.17 and 95% confidence interval (CI) of 1.56-6.50, and so was BPD (OR 1.52, 95% CI: 1.03-2.2). The combination of two neonatal morbidities increased the risk of a poor outcome (OR 4.44, 95% CI: 1.51-7.86). The model behaved differently in the two subcohorts.<bold>Conclusion: </bold>The prognostic model predicted a poor outcome at seven years of age when the subjects had at least two of the three morbidities.
- Subjects
MADRID (Spain); PREMATURE infants; EARLY death; BRONCHOPULMONARY dysplasia; BIRTH weight; RETROLENTAL fibroplasia
- Publication
Acta Paediatrica, 2019, Vol 108, Issue 7, p1245
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.14679