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- Title
Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion.
- Authors
Biskup, C. S.; Helmbold, K.; Baurmann, D.; Klasen, M.; Gaber, T. J.; Bubenzer‐Busch, S.; Königschulte, W.; Fink, G. R.; Zepf, F. D.
- Abstract
Objective: Alterations of the default mode network (DMN) have been described in patients with neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), and the neurotransmitter serotonin (5-HT) is known to modulate DMN activity. This study aimed to explore the role of 5-HT on the DMN and its functional connectivity (FC) in young patients with ADHD. Methods: Young male patients with ADHD (n = 12) and healthy controls (n = 10) (both aged 12-17 years) were subjected to acute tryptophan depletion (ATD) and subsequently diminished brain 5-HT synthesis. Three hours after challenge intake (ATD or a balanced control condition, BAL), resting state fMRI scans were obtained. Results: In patients, ATD led to attenuated FC of the right superior premotor cortex (BA 6) with the DMN, comparable to the extent found in controls after BAL administration. ATD lowered FC of the left somatosensory cortex (BA 3) with the DMN, independently of the factor group, but with stronger effects in controls. Conclusions: Data reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN, thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD.
- Subjects
ADOLESCENT psychopathology; ATTENTION-deficit hyperactivity disorder; CHILD psychology; MENTAL health; PSYCHIATRIC diagnosis; SOMATOSENSORY cortex; TRYPTOPHAN derivatives; FUNCTIONAL magnetic resonance imaging
- Publication
Acta Psychiatrica Scandinavica, 2016, Vol 134, Issue 2, p161
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12573