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- Title
CBF and CMRO2 during continuous etomidate infusion supplemented with N2O and fentanyl in patients with supratentorial cerebral tumour. A dose-response study.
- Authors
COLD, G. E.; ESKESEN, V.; ERIKSEN, H.; AMTOFT, O.; MADSEN, J. B.
- Abstract
In 14 patients with supratentorial cerebral tumours with midline shift below 10 mm, CBF and CMRO2 were measured (Kety & Schmidt) during craniotomy. The anaesthesia was continuous etomidate infusion supplemented with nitrous oxide and fentanyl. The patients were divided into two groups. In Group 1 etomidate infusion of 30 micrograms kg-1 min-1 was used throughout the anaesthesia, and CBF and CMRO2 were measured twice. In this group CMRO2 (means +/- s.d.) averaged 2.31 +/- 0.43 ml O2 100 g-1 min-1 70 min after induction and 2.21 +/- 0.38 ml O2 100 g-1 min-1 130 min after induction. In Group 2 the etomidate infusion was increased from 30 to 60 micrograms kg-1 min-1 after the first study and a significant fall in CMRO2 from 2.52 +/- 0.56 to 1.76 +/- 0.40 ml O2 100 g-1 min-1 was found. Simultaneously, a significant fall in CBF was observed. The CO2 reactivity was preserved during anaesthesia.
- Subjects
BRAIN metabolism; ANESTHETICS; CEREBRAL circulation; OXYGEN consumption; FENTANYL; GLIOMAS; BRAIN tumors; IMIDAZOLES; MENINGIOMA; CARBON dioxide; DRUG interactions; DOSE-effect relationship in pharmacology; NITROUS oxide; ETOMIDATE; PHARMACODYNAMICS
- Publication
Acta Anaesthesiologica Scandinavica, 1985, Vol 29, Issue 5, p490
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1111/j.1399-6576.1985.tb02240.x