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- Title
Prospective prenatal serum screening for Down syndrome in Venezuela
- Authors
Álvarez-Nava, Francisco; Soto, Marisol; Morales-Machín, Alisandra; Rojas, Alicia; Urdaneta, Karelis; Cañizález, Jenny; Alvarez-Nava, Francisco; Morales-Machín, Alisandra; Cañizález, Jenny
- Abstract
<bold>Objective: </bold>To assess the usefulness of triple-marker screening for Down syndrome in Venezuela.<bold>Method: </bold>Maternal serum concentrations of alpha fetoprotein (AFP), beta human chorionic gonadotropin (beta-hCG), and unconjugated estriol (uE3) were measured weekly in 3895 women from the 15th to the 20th week of pregnancy. Population-specific likelihood ratios were determined and used to calculate the risk of fetal Down syndrome for each pregnancy.<bold>Results: </bold>The median multiple of the median values for AFP, beta-hCG, and uE3 concentrations were 0.69, 2.10, and 0.67 for the affected pregnancies. The likelihood ratio for a positive result was 1:19. The detection and false-positive rates were 69.23% and 5.8%.<bold>Conclusion: </bold>These findings were consistent with reported data and therefore confirmed triple-marker serum screening as effective and suitable for prenatal care in Venezuela. Latin American governments and Health Agencies should recommend offering this screening method to all pregnant women.
- Subjects
VENEZUELA; PRENATAL diagnosis; SERUM; MEDICAL screening; DOWN syndrome; DIAGNOSIS of Down syndrome; ALPHA fetoproteins; CHORIONIC gonadotropins; COMPARATIVE studies; DIAGNOSTIC errors; LONGITUDINAL method; MATERNAL age; RESEARCH methodology; MEDICAL cooperation; NONPARAMETRIC statistics; SECOND trimester of pregnancy; REFERENCE values; RESEARCH; LOGISTIC regression analysis; EVALUATION research; PREDICTIVE tests; ESTRIOL
- Publication
International Journal of Gynecology & Obstetrics, 2008, Vol 103, Issue 3, p241
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2008.07.017