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- Title
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension.
- Authors
Pizzo, Thayane Rafaela Feola; Valverde, Ana Paula; Orzari, Lucas Eduardo; Terciotti, Luiz Gustavo; de Lima, Robson Damasceno; Costa do Bomfim, Fernando Russo; Esquisatto, Marcelo Augusto Marreto; de Andrade, Thiago Antônio Moretti; Corezola do Amaral, Maria Esméria; de Oliveira, Camila Andrea; Felonato, Maíra
- Abstract
Renovascular hypertension (RHV) is the cause of high blood pressure due to left renal ischemia, and obesity and hypertension cause an inflammatory response. This work analyzed the inflammatory and tissue repair profile in renal, hepatic, and cardiac tissues in an animal model of RVH associated with a high-fat diet and caloric restriction. The expressions of RORγ-t, IL-17, T-bet, and TNF-α decreased and IFN-γ increased in the right kidney. In relation to the left kidney, caloric restriction decreased the expression of IFN-γ. In the liver, caloric restriction decreased RORγ-t, IL-17, and T-bet. Hypertension associated with obesity decreased the expression of IFN-γ, while caloric restriction increased. In the right kidney, hypertension and obesity, associated or not with caloric restriction, increased the area of collagen fibers. In the heart and liver, caloric restriction reduced the area of collagen fibers. Caloric restriction increased vascular endothelial growth factor, reduced levels of growth transformation factor-β1 (TGF-β), and increased collagen I in the left kidney. Hypertension/obesity, submitted or not having caloric restriction, increased TGF-β in liver. The results suggest that caloric restriction has beneficial effects in lowering blood pressure and regulating tissue proinflammatory cytokines. However, there was no change in the structure and composition of tissue repair markers.
- Subjects
LOW-calorie diet; RENOVASCULAR hypertension; VASCULAR endothelial growth factors; LABORATORY rats; KIDNEYS; HIGH-fat diet; HEART
- Publication
Canadian Journal of Physiology & Pharmacology, 2023, Vol 101, Issue 12, p661
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2022-0452