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In silico evidence of bitopertin's broad interactions within the SLC6 transporter family.
Published in:
Journal of Pharmacy & Pharmacology, 2024, v. 76, n. 9, p. 1199, doi. 10.1093/jpp/rgae051
By:
- de Carvalho, Gustavo Almeida;
- Tambwe, Paul Magogo;
- Nascimento, Lucas Rodrigues Couto;
- Campos, Bruna Kelly Pedrosa;
- Chiareli, Raphaela Almeida;
- Junior, Guilhermino Pereira Nunes;
- Menegatti, Ricardo;
- Gomez, Renato Santiago;
- Pinto, Mauro Cunha Xavier
Publication type:
Article
Chrysin bonded to β-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice.
Published in:
Journal of Pharmacy & Pharmacology, 2024, v. 76, n. 4, p. 368, doi. 10.1093/jpp/rgae011
By:
- Okoh, Victor Ifeanyi;
- Campos, Hericles Mesquita;
- Yasmin de Oliveira Ferreira, Pâmela;
- Pereira, Robbert Mota;
- Souza Silva, Yohanny;
- Arruda, Evilanna Lima;
- Pagliarani, Barbara;
- de Almeida Ribeiro Oliveira, Gerlon;
- Lião, Luciano Morais;
- Franco dos Santos, Gabriel;
- Vaz, Boniek Gontijo;
- Sabino, José Ricardo;
- Alcantara dos Santos, Fernanda Cristina;
- Costa, Elson Alves;
- Tarozzi, Andrea;
- Menegatti, Ricardo;
- Ghedini, Paulo César
Publication type:
Article
Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor - LQFM030.
Published in:
Journal of Pharmacy & Pharmacology, 2016, v. 68, n. 9, p. 1143, doi. 10.1111/jphp.12573
By:
- Mota, Mariana F.;
- Cortez, Alane P.;
- Benfica, Polyana L.;
- Rodrigues, Bruna dos S.;
- Castro, Thalyta F.;
- Macedo, Larissa M.;
- Castro, Carlos H.;
- Lião, Luciano M.;
- Carvalho, Flávio S.;
- Romeiro, Luiz A. S.;
- Menegatti, Ricardo;
- Verli, Hugo;
- Villavicencio, Bianca;
- Valadares, Marize C.
Publication type:
Article
Anti-inflammatory effect of ( E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol.
Published in:
Journal of Pharmacy & Pharmacology, 2013, v. 65, n. 1, p. 133, doi. 10.1111/j.2042-7158.2012.01582.x
By:
- Lino, Roberta Campos;
- Martins, Fabiula Ines;
- Florentino, Iziara Ferreira;
- Nascimento, Marcus Vinicius Mariano;
- Galdino, Pablinny Moreira;
- Andrade, Carolina H.;
- Rezende, Kênnia Rocha;
- Menegatti, Ricardo;
- Costa, Elson Alves
Publication type:
Article
Bioanalytical LC-QTOF/MS Method for a N -phenylpiperazine Derivate (LQFM05): An Anxiolytic- and Antidepressant-like Prototype Drug Applied to Pharmacokinetic and Biodistribution Studies.
Published in:
Pharmaceuticals (14248247), 2023, v. 16, n. 7, p. 930, doi. 10.3390/ph16070930
By:
- Ramos, Ana Cláudia M.;
- Rezende, Kênnia R.;
- Teixeira, Carolina M.;
- Fernandes, Aline R.;
- Santos, Heloa;
- Machado, Rúbia Darc;
- Menegatti, Ricardo;
- Vaz, Boniek G.;
- Chaves, Andréa R.
Publication type:
Article
Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory Calculations.
Published in:
Pharmaceuticals (14248247), 2019, v. 12, n. 3, p. 116, doi. 10.3390/ph12030116
By:
- Rodrigues, Edson Silvio Batista;
- de Macêdo, Isaac Yves Lopes;
- da Silva Lima, Larissa Lesley;
- Thomaz, Douglas Vieira;
- da Cunha, Carlos Eduardo Peixoto;
- Teles de Oliveira, Mayk;
- Ballaminut, Nara;
- Alecrim, Morgana Fernandes;
- Ferreira de Carvalho, Murilo;
- Isecke, Bruna Guimarães;
- Carneiro de Siqueira Leite, Karla;
- Machado, Fabio Bahls;
- Guimarães, Freddy Fernandes;
- Menegatti, Ricardo;
- Somerset, Vernon;
- de Souza Gil, Eric
Publication type:
Article
Anxiolytic-like effect of 2-(4-((1-phenyl-1 H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathways.
Published in:
Chemical Biology & Drug Design, 2017, v. 90, n. 3, p. 432, doi. 10.1111/cbdd.12961
By:
- Brito, Adriane F.;
- Fajemiroye, James O.;
- Neri, Hiasmin F. S.;
- Silva, Dayane M.;
- Silva, Daiany P. B.;
- Sanz, Germán;
- Vaz, Boniek G.;
- Carvalho, Flávio S.;
- Ghedini, Paulo C.;
- Lião, Luciano M.;
- Menegatti, Ricardo;
- Costa, Elson A.
Publication type:
Article
New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities.
Published in:
Chemical Biology & Drug Design, 2017, v. 89, n. 1, p. 124, doi. 10.1111/cbdd.12838
By:
- Oliveira, Lanussy Porfiro;
- Silva, Daiany Priscilla Bueno;
- Florentino, Iziara Ferreira;
- Fajemiroye, James Oluwagbamigbe;
- Oliveira, Thiago Sardinha;
- Marcelino, Renato Ivan de Ávila;
- Pazini, Francine;
- Lião, Luciano Morais;
- Ghedini, Paulo César;
- Moura, Soraia Santana;
- Valadares, Marize Campos;
- Carvalho, Verônica Vale;
- Vaz, Boniek Gontijo;
- Menegatti, Ricardo;
- Costa, Elson Alves
Publication type:
Article
Complete assignment of NMR data of 22 phenyl-1 H-pyrazoles' derivatives.
Published in:
Magnetic Resonance in Chemistry, 2011, v. 49, n. 8, p. 537, doi. 10.1002/mrc.2773
By:
- de Oliveira, Aline Lima;
- Alves de Oliveira, Carlos Henrique;
- Mairink, Laura Maia;
- Pazini, Francine;
- Menegatti, Ricardo;
- Lião, Luciano Morais
Publication type:
Article
Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.
Published in:
Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.666725
By:
- Costa, Rafael Fernades;
- Turones, Larissa Córdova;
- Cavalcante, Keilah Valéria Naves;
- Rosa Júnior, Ismael Aureliano;
- Xavier, Carlos Henrique;
- Rosseto, Lucimar Pinheiro;
- Napolitano, Hamilton Barbosa;
- Castro, Patrícia Ferreira da Silva;
- Neto, Marcos Luiz Ferreira;
- Galvão, Gustavo Mota;
- Menegatti, Ricardo;
- Pedrino, Gustavo Rodrigues;
- Costa, Elson Alves;
- Martins, José Luis Rodrigues;
- Fajemiroye, James Oluwagbamigbe
Publication type:
Article
LQFM184: A Novel Wide Ultraviolet Radiation Range Absorber Compound.
Published in:
Photochemistry & Photobiology, 2021, v. 97, n. 2, p. 360, doi. 10.1111/php.13349
By:
- Vinhal, Daniela C.;
- Ivan de Ávila, Renato;
- Rodrigues, Thaisângela L.;
- Silva, Andressa K.;
- Moreira, Larissa C.;
- Valadares, Marize C.;
- Luzin, Rangel M.;
- Lião, Luciano M.;
- Gil, Eric de S.;
- Vaz, Boniek G.;
- Assis, Rogério J.;
- Gonçalves, Pablo J.;
- Isaac, Vera;
- da Cunha, Luiz C.;
- Menegatti, Ricardo
Publication type:
Article
Electrospray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties.
Published in:
Journal of Mass Spectrometry, 2005, v. 40, n. 6, p. 815, doi. 10.1002/jms.857
By:
- Santos, Leonardo S.;
- Padilha, Monica Costa;
- de Aquino Neto, Francisco Radler;
- Santos Pereira, Alberto dos;
- Menegatti, Ricardo;
- Manssour Fraga, Carlos Alberto;
- Barreiro, Eliezer J.;
- Eberlin, Marcos N.
Publication type:
Article
Novel Proline Transporter Inhibitor (LQFM215) Presents Antipsychotic Effect in Ketamine Model of Schizophrenia.
Published in:
Neurochemical Research, 2024, v. 49, n. 1, p. 170, doi. 10.1007/s11064-023-04018-3
By:
- Carvalho, Gustavo Almeida;
- Chiareli, Raphaela Almeida;
- Pedrazzi, João Francisco Cordeiro;
- Silva-Amaral, Danyelle;
- da Rocha, André Luís Batista;
- Oliveira-Lima, Onésia Cristina;
- Lião, Luciano Morais;
- de Souza-Fagundes, Elaine Maria;
- Schildknecht, Stefan;
- Leist, Marcel;
- Del-Bel, Elaine Aparecida;
- Gomez, Renato Santiago;
- Birbrair, Alexander;
- Menegatti, Ricardo;
- Pinto, Mauro Cunha Xavier
Publication type:
Article
Preclinical data on morpholine (3,5-di-tertbutyl-4-hydroxyphenyl) methanone induced anxiolysis.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 11, p. 2957, doi. 10.1007/s00210-023-02502-9
By:
- Cabral, Iara Barbosa;
- de Lima Moreira, Caroline Vitória;
- Rodrigues, Ana Carolina Cavalcante;
- da Silva Moreira, Lorrane Kelle;
- Pereira, Jhon Kennedy Alves;
- Gomides, Christian Dias;
- Lião, Luciano M.;
- Machado, Lucas S.;
- Vaz, Boniek G.;
- da Cunha, Luiz Carlos;
- de Oliveira Neto, Jerônimo Raimundo;
- da Silva-Júnior, Edeildo Ferreira;
- de Aquino, Thiago Mendonça;
- da Silva Santos-Júnior, Paulo Fernando;
- Silva, Osmar N.;
- da Rocha, Fábio Fagundes;
- Costa, Elson Alves;
- Menegatti, Ricardo;
- Fajemiroye, James O.
Publication type:
Article
Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2019, v. 392, n. 9, p. 1071, doi. 10.1007/s00210-019-01649-8
By:
- Menegatti, Ricardo;
- Carvalho, Flávio S.;
- Lião, Luciano M.;
- Villavicencio, Bianca;
- Verli, Hugo;
- Mourão, Aline A.;
- Xavier, Carlos H.;
- Castro, Carlos H.;
- Pedrino, Gustavo R.;
- Franco, Octavio L.;
- Oliveira-Silva, Iransé;
- Ashpole, Nicole M.;
- Silva, Osmar Nascimento;
- Costa, Elson A.;
- Fajemiroye, James O.
Publication type:
Article
A new piperazine derivative: 1-(4-(3,5-di-<italic>tert</italic>-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2018, v. 391, n. 3, p. 255, doi. 10.1007/s00210-017-1451-7
By:
- Brito, Adriane F.;
- Braga, Patrícia C. C. S.;
- Moreira, Lorrane K. S.;
- Silva, Dayane M.;
- Silva, Daiany P. B.;
- Sanz, Germán;
- Vaz, Boniek G.;
- de Carvalho, Flávio S.;
- Lião, Luciano M.;
- Silva, Rafaela R.;
- Noël, François;
- Neri, Hiasmin F. S.;
- Ghedini, Paulo C.;
- de Carvalho, Murilo F.;
- de S. Gil, Eric;
- Costa, Elson A.;
- Menegatti, Ricardo
Publication type:
Article
Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D<sub>2</sub> Receptor.
Published in:
Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00628
By:
- Silva, Rafaela R.;
- Parreiras-e-Silva, Lucas T.;
- Pompeu, Thais E.T.;
- Duarte, Diego A.;
- Fraga, Carlos A.M.;
- Barreiro, Eliezer J.;
- Menegatti, Ricardo;
- Costa-Neto, Claudio M.;
- Noël, François
Publication type:
Article
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels.
Published in:
Canadian Journal of Physiology & Pharmacology, 2023, v. 101, n. 5, p. 216, doi. 10.1139/cjpp-2022-0428
By:
- de Oliveira, Lanussy P.;
- Florentino, Iziara F.;
- Silva, Daiany P.B.;
- Pazini, Francine;
- de Carvalho, Flávio S.;
- Sanz, Germán;
- Vaz, Boniek G.;
- da Rocha, Fábio F.;
- Fajemiroye, James O.;
- Ghedini, Paulo C.;
- Lião, Luciano M.;
- Menegatti, Ricardo;
- Costa, Elson A.;
- de Oliveira, Thiago S.
Publication type:
Article
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects.
Published in:
Canadian Journal of Physiology & Pharmacology, 2022, v. 100, n. 6, p. 521, doi. 10.1139/cjpp-2021-0729
By:
- Santana, Ianca Gontijo Cavalcante;
- Almeida, Lorena de Souza;
- Moreira, Lorrane Kelle da Silva;
- de Carvalho, Flávio Silva;
- Menegatti, Ricardo;
- da Rocha, André Luis Batista;
- Mazurok, Thais Aline;
- Vaz, Boniek Gontijo;
- Lião, Luciano Morais;
- Brito, Adriane Ferreira de;
- Fajemiroye, James Oluwagbamigbe;
- Costa, Elson Alves;
- de Carvalho, Pablinny Moreira Galdino
Publication type:
Article
Small‐molecule MDM2 inhibitor LQFM030‐induced apoptosis in p53‐null K562 chronic myeloid leukemia cells.
Published in:
Fundamental & Clinical Pharmacology, 2020, v. 34, n. 4, p. 444, doi. 10.1111/fcp.12540
By:
- Oliveira Ribeiro, Higor;
- Cortez, Alane Pereira;
- Ávila, Renato Ivan;
- Silva, Artur Christian Garcia;
- Carvalho, Flávio Silva;
- Menegatti, Ricardo;
- Lião, Luciano Morais;
- Valadares, Marize Campos
Publication type:
Article
Piperazine derivatives with central pharmacological activity used as therapeutic tools.
Published in:
Fundamental & Clinical Pharmacology, 2019, v. 33, n. 1, p. 13, doi. 10.1111/fcp.12408
By:
- Brito, Adriane F.;
- Moreira, Lorrane K. S.;
- Menegatti, Ricardo;
- Costa, Elson A.
Publication type:
Article
Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs.
Published in:
Frontiers in Psychiatry, 2019, p. N.PAG, doi. 10.3389/fpsyt.2019.00157
By:
- Zjawiony, Jordan K.;
- Machado, Antônio S.;
- Menegatti, Ricardo;
- Ghedini, Paulo C.;
- Costa, Elson A.;
- Pedrino, Gustavo R.;
- Lukas, Scott E.;
- Franco, Octávio L.;
- Silva, Osmar N.;
- Fajemiroye, James O.
Publication type:
Article
LQFM289: Electrochemical and Computational Studies of a New Trimetozine Analogue for Anxiety Treatment.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14575, doi. 10.3390/ijms241914575
By:
- Pereira, Jhon K. A.;
- Costa, André G. C.;
- Rodrigues, Edson S. B.;
- Macêdo, Isaac Y. L.;
- Pereira, Marx O. A.;
- Menegatti, Ricardo;
- de Oliveira, Severino C. B.;
- Guimarães, Freddy;
- Lião, Luciano M.;
- Sabino, José R.;
- de S. Gil, Eric
Publication type:
Article
The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1 H -Pyrazol-4-yl)-2 H -Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway.
Published in:
Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01073
By:
- Trindade, Neidiane R.;
- Lopes, Paulo R.;
- Naves, Lara M.;
- Amaral, Nathalia O.;
- Pedrino, Gustavo R.;
- Fajemiroye, James O.;
- Menegatti, Ricardo;
- Alves, Pedro H.;
- Castro, Carlos H.;
- Lião, Luciano M.;
- Rebelo, Ana C. S.;
- Braga, Valdir A.
Publication type:
Article

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