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- Title
Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig.
- Authors
Ruane-O'Hora, Therese; Shortt, Christine M.; Edge, Deirdre; Markos, Farouk; Noble, Mark I.M.
- Abstract
The effect of intraluminal hyperglycaemia was investigated in the iliac artery of 11 anaesthetised pigs. Following isolation of a test segment, hyperglycaemic blood (40 mmol·L-1) caused a significant dilatation of the artery of 167 ± 208 μm (mean ± SD; n = 6, P = 0.031). Dilatations were reduced by N(G)-nitro- l-arginine methyl esther (250 μg·mL-1) from 145 ± 199 to 38 ± 5 μm), but this was not statistically significant ( n = 6, P = 0.18). Intra-arterial infusions of d-glucose (20-40 mmol·L-1·min-1), during graded constrictions, caused statistically significant increases in blood flow ( n = 11, P = 0.0013). Vasodilatation was confirmed by measurements of the ratio of immediate pressure steps to flow steps (∂ P/∂ F) during the graded obstruction experiments, showing a decrease in instantaneous vascular resistance from a control of 0.62 ± 0.30 to 0.33 ± 0.34 mm Hg·mL-1·min-1 ( n = 7, P = 0.016). Autoregulation was assessed from the slopes of the plots of steady-state flow versus pressure. There were significant increases in the slope from 2.32 ± 1.03 to 5.88 ± 5.60 mL·min-1·(mm Hg)-1 ( n = 7, P = 0.0078), indicating significant impairment of autoregulation. In conclusion, luminal hyperglycaemia relaxes both arterial and resistance vessel smooth muscle.
- Subjects
HYPERGLYCEMIA; AQUEDUCTS; BLOOD-vessel physiology; ANESTHESIA; LABORATORY swine
- Publication
Canadian Journal of Physiology & Pharmacology, 2013, Vol 91, Issue 12, p1031
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2013-0206