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- Title
Roles of guanylyl cyclase-A signaling in the cardiovascular system.
- Authors
Saito, Yoshihiko; Kishimoto, Ichiro; Nakao, Kazuwa
- Abstract
Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones synthesized in and secreted from the heart. ANP and BNP bind the common receptor guanylyl cyclase-A (GC-A) and possess biological actions. Based on their diuretic, natriuretic, and vasodilating activities, they are now widely used as therapeutic agents for heart failure. Roles of endogenous ANP and BNP have been investigated using mice lacking the gene encoding GC-A. Here we describe the recent understanding of roles of GC-A in the cardiovascular system.
- Subjects
GUANYLATE cyclase; ATRIAL natriuretic peptides; DIURETICS; HEART failure; PEPTIDE hormones; GENETIC code; CARDIOVASCULAR diseases
- Publication
Canadian Journal of Physiology & Pharmacology, 2011, Vol 89, Issue 8, p551
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/y11-022