We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Racecadotril versus placebo in the treatment of acute diarrhoea in adults.
- Authors
Hamza, H.; Ben Khalifa, H.; Baumer, P.; Berard, H.; Lecomte, J.M.
- Abstract
Methods A two-centre, double-blind, parallel-group, randomized study was carried out to compare the efficacy and tolerability of racecadotril (100 mg three times daily) and placebo in 70 adult patients with acute diarrhoea. An objective criterion of antisecretory activity, stool weight, was used. Results Racecadotril produced a significant (P = 0.025) decrease in stool weight during the first day of treatment compared with placebo, and was also associated with significantly fewer diarrhoeic stools than placebo after 1 day of treatment (P = 0.02 7). Racecadotril and placebo were equally well tolerated, and the frequency of symptoms and signs was similar in both groups after 4 days of treatment. Fewer patients on racecadotril suffered from abdominal distension following treatment (5.6% vs. 18.2% on placebo). Conclusions Racecadotril acts rapidly to resolve acute diarrhoea and has an incidence of adverse events similar to that of placebo.
- Subjects
ANTIDIARRHEALS; PLACEBOS; DIARRHEA; THERAPEUTICS; DIARRHEA in old age; DRUG efficacy
- Publication
Alimentary Pharmacology & Therapeutics, 1999, Vol 13, p15
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.1999.00002.x-i1