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- Title
Seminal Calbindin 2 in Infertile Men With Varicocele: A Prospective Comparative Study.
- Authors
GamalEl Din, Sameh Fayek; Zeidan, Ashraf; Salam, Mohamed Ahmed Abdel; El Kader, Noha Abd EL Hafeez Abd; Mohamed, Sara Ahmed; Azmy, Mohamed Farag
- Abstract
The present study compared seminal calbindin 2 (CALB 2) levels and semen parameters in men with and without varicocele. CALB 2 is also known as calretinin and 29 kDa calbindin. The study was a case-control study conducted from April (2021) to March (2022) in the andrology department at Beni-Suef University hospital. The study included four matched groups: group (I) were controls (fertile normozoospermic men without varicocele) (n=24). Group (II) were fertile normozoospermic men with varicocele (n=24). Group (III) were infertile oligoasthenoteratozoospermia (OAT) men without varicocele (n=24). Group (IV) were infertile OAT men with varicocele (n=24). The lowest levels of seminal CALB 2 were found in patients with severe oligozoospermia which showed a statistically significant difference when compared to seminal CALB 2 in patients with normal, mildly low, or moderately low sperm counts. There were significant negative correlations between sperm concentration, sperm motility and percentage of normal sperm forms and seminal CALB 2. Seminal plasma CALB 2 may play a role in the negative impact of varicocele on the semen parameters especially sperm concentration, sperm motility and percentage of sperm normal forms. Future studies are needed to verify these findings.
- Publication
Reproductive Sciences, 2023, Vol 30, Issue 10, p3077
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1007/s43032-023-01237-5