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- Title
Association of Mouse Major Histocompatibility and Rauscher Murine Leukaemia Virus Envelope Glycoprotein Antigens on Leukaemia Cells and their Recognition by Syngeneic Virus--Immune--CytotoxicT--Lymphocytes.
- Authors
Zarling, D.A.; Keshet, I.; Watson, A.; Bach, F.H.
- Abstract
Physical association was measured between MLV gp70, the envelope glycoprotein of Rauscher murine leukaemia virus (R-MLV), and serologically defined H-2 antigens on the surface of R-MLV transformed C57BL/6 (H-2DbKb) mouse leukaemia cells (RBL-5A). Capping and patching with antisera against H-2Db caused specific co-capping and co-patching of R-MLV gp70 antigens as seen by fluorescence microscopy. Despite the physical proximity of R-MLV gp70 and H-2Db antigens, high titre αR-MLV gp70 sera had no effect in blocking syngeneic T-lymphocyte mediated cytolysis of RBL-5A cells whereas αH-2Db sera were effective.
- Subjects
MOUSE leukemia viruses; MOUSE leukemia; GLYCOPROTEINS; CANCER cells; IMMUNE serums; IMMUNOGLOBULINS
- Publication
Scandinavian Journal of Immunology, 1978, Vol 8, Issue 6, p497
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1978.tb00549.x