We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Persistent Ex Vivo Low Number and Functional In Vitro Recovery of Circulating γδ T Cells after Removal of a Cutaneous Primary Melanoma.
- Authors
Provinciali, M.; Re, F.; Tucci, M. G.; Ricotti, F.; Lattanzio, F.
- Abstract
We recently described γδ T cells alterations in patients with a cutaneous primary melanoma. To evaluate whether γδ T cells alterations persisted after melanoma removal, we performed a follow-up study comparing the number and function of γδ T lymphocytes from 19 subjects, 4 years after the removal of a cutaneous primary melanoma, with the data obtained in the same subjects before the surgical intervention and with control donors. The number of circulating γδ+ T cells after melanoma removal was not recovered to the levels found in controls. γδ+ T cells producing TNF-α or IFN-γ were increased after melanoma removal in comparison with the same subjects before surgical intervention or with control donors. After in vitro culture, both the percentage and the expansion of γδ T cells were recovered to the values found in controls. In conclusion, the functional capacity of γδ T cells was in vitro recovered after melanoma removal, whereas their ex vivo number remained at lower levels than control donors.
- Subjects
T cells; MELANOMA; LYMPHOCYTES; LEUCOCYTES; NEUROENDOCRINE tumors
- Publication
Scandinavian Journal of Immunology, 2010, Vol 72, Issue 2, p142
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2010.02413.x