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- Title
Expression of Interleukin-22 in Murine Carcinoma Cells did not Influence Tumour GrowthIn Vivobut did Improve Survival of the Inoculated Hosts.
- Authors
Nagakawa, H.; Shimozato, O.; Yu, L.; Takiguchi, Y.; Tatsumi, K.; Kuriyama, T.; Tagawa, M.
- Abstract
Interleukin (IL)-22, a novel cytokine belonging to the IL-10 family, is secreted from activated T and natural killer cells and is possibly involved in inflammatory responses. We examined whether expression of theIL-22gene in murine colon carcinoma Colon 26 cells (Colon 26/IL-22) could produce any antitumour effects in the inoculated mice. Although growth of Colon 26/IL-22 tumours in syngeneic mice was not different from that of parent tumours, survival of the mice that were subcutaneously or intraperitoneally inoculated with Colon 26/IL-22 tumours was significantly prolonged compared with the mice inoculated with parent tumours. Metastasis was not influenced by IL-22 expressed in tumours. Expression of the IL-22 receptor-specific gene,IL-22R, was not induced in spleen cells stimulated with concanavalin A, anti-CD3 or anti-CD40 antibody, despite constitutive expression of theIL-10R2gene, which encodes another component of the heterodimeric IL-22 receptor complex. IL-22 thereby does not directly act on immunocompetent cells, and IL-22 expressed in tumours can favour apothanasia of inoculated hosts.
- Subjects
INTERLEUKINS; INTERLEUKIN-10; CANCER; IMMUNE system; MICE; CANCER invasiveness
- Publication
Scandinavian Journal of Immunology, 2004, Vol 60, Issue 5, p449
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.0300-9475.2004.01504.x